Summary. Background: Recently, bioactive ceramics based on hydroxyapatite (HAP) and tricalcium phosphate (TCP) have been preferred as implants in bone engineering. Aim: To study bone regeneration under conditions of filling metaphyseal defects with the original HAP-TCP composition. Materials and Methods: The experiment was carried out on inbred rats, the observation period was 2, 4, 8 weeks. Morphological studies were carried out using light and electron microscopy. Results: In the dynamics of observation at 2, 4 and 8 weeks, a gradual arrangement of osteoclasts and osteoblasts on the surface of HAP-TCP was recorded, which indicates its high biocompatibility with bone tissue. During the experiment, the processes of resorption of implants, mineralization, proliferation of cellular elements of collagen and osteogenesis (osteoblasts and osteoclasts) and the formation of mature bone tissue were recorded. Conclusions. Experimental studies of plastic bone defects proved the presence of the osteoinductive and osteointegrative effect of HAP-TCP composition, which contributes to a more dynamic uncomplicated course of reparative osteogenesis.

The purpose of the investigation is to study biochemical markers of bone metabolism in patients with breast cancer and prostate cancer during periods of stable remission and recurrence/metastasis and to assess their informative value in the diagnosis and monitoring of skeletal lesions. The study included 21 female patients with breast cancer and 18 male patients with prostate cancer. The start of monitoring is at least 3 years after complete tumor regression as a result of treatment: breast cancer – radical mastectomy, prostate cancer – radical prostatectomy. Markers of bone resorption (urine deoxypyridinoline, C-terminal telopeptide and tartrate-resistant acid phosphatase of blood serum) and osteogenesis (bone alkaline phosphatase and osteocalcin of blood serum) in patients with breast cancer and prostate cancer can be used for early diagnosis of metastasis in the skeleton bones: changes in indicators are observed 6-10 months before the first radiological/ MRI signs appear. The application of simultaneously used markers of bone resorption and osteogenesis in patients with breast cancer and prostate cancer provides a sensitivity of 89.7 %, a specificity of 84.5 %, a positive predictive value of 82.6 % and a negative predictive value of 95.3 %.

The potential field of magnetic resonance spectroscopy (MRS) application in the clinical practice of oncology is trivial: differential diagnosis of tumors, analysis of tumor malignancy degree, visualization of tumor response to chemotherapy, radiation therapy, and prediction of treatment outcome. The purpose of the work is to present, within the framework of infographics, the initial visual data of MRS of malignant tumors of various localizations for promising multiplatform systems of scientific visualization. Recall that scientific visualization deals with issues of accurate and understandable display of objects, processes and phenomena of scientific/practical interest. In the aspect of infographics, representative spectra of normal and tumor of brain tissues, auditory nerve, thyroid gland, lungs, mammary gland, pancreas, liver, kidneys, ovaries, uterus, prostate gland, muscles, and bones are presented. The main defined 1H-MPC tumor metabolites are described. Many tumors are overlapped in spectrum, and MRI results are best interpreted in conjunction with other imaging and histological analysis findings. The potential of MRS technologies can be fully realized only in superposition with artificial intellect.