A formal validation study was performed, in order to investigate whether the commercially-available reconstructed human epidermis (RHE) models, EPISKIN®, EpiDerm™ and SkinEthic®, are suitable for in vitro skin absorption testing. The skin types currently recommended in the OECD Test Guideline 428, namely, ex vivo human epidermis and pig skin, were used as references. Based on the promising outcome of the prevalidation study, the panel of test substances was enlarged to nine substances, covering a wider spectrum of physicochemical properties. The substances were tested under both infinite-dose and finite-dose conditions, in ten laboratories, under strictly controlled conditions. The data were subjected to independent statistical analyses. Intra-laboratory and inter-laboratory variability contributed almost equally to the total variability, which was in the same range as that in preceding studies. In general, permeation of the RHE models exceeded that of human epidermis and pig skin (the SkinEthic RHE was found to be the most permeable), yet the ranking of substance permeation through the three tested RHE models and the pig skin reflected the permeation through human epidermis. In addition, both infinite-dose and finite-dose experiments are feasible with RHE models. The RHE models did not show the expected significantly better reproducibility, as compared to excised skin, despite a tendency toward lower variability of the data. Importantly, however, the permeation data showed a sufficient correlation between all the preparations examined. Thus, the RHE models, EPISKIN, EpiDerm and SkinEthic, are appropriate alternatives to human and pig skin, for the in vitro assessment of the permeation and penetration of substances when applied as aqueous solutions.

Isotope shifts in dielectronic recombination spectra were studied for Li-like A Nd 57+ ions with A=142 and A=150. From the displacement of resonance positions energy shifts δE 142,150 (2s − 2p 1/2 ) = 40.2(3)(6) meV ((stat)(sys)) and δE 142,150 (2s − 2p 3/2 ) = 42.3(12)(20) meV of 2s − 2p j transitions were deduced. An evaluation of these values within a full QED treatment yields a change in the mean-square charge radius of 142,150 δ r 2 = -1.36(1)(3) fm 2 . The approach is conceptually new and combines the advantage of a simple atomic structure with high sensitivity to nuclear size.

Term energies for dielectronic-recombination Rydberg resonances below 0.07 eV are determined for Sc18+ with absolute accuracies below 0.0002 eV by electron collision spectroscopy in an ion storage ring, using the twin-electron-beam technique and a cryogenic photocathode. The lithiumlike 2s_{1/2}-2p_{3/2} transition energy for Z=21 is determined to 4.6 ppm, less than 1% of the few-body effects on radiative corrections. Features from the hyperfine structure of the 2s state could be resolved in the dielectronic-recombination spectrum.

Recent spectroscopic models of active galactic nuclei (AGN) have indicated that the recommended electronion recombination rate coefficients for iron ions with partially filled M-shells are incorrect in the temperature range where these ions form in photoionized plasmas. We have investigated this experimentally for Fe XIV forming Fe XIII. The recombination rate coefficient was measured employing the electron-ion merged beams method at the Heidelberg heavy-ion storage-ring TSR. The measured energy range of 0 − 260 eV encompassed all dielectronic recombination (DR) 1s 2 2s 2 2p 6 3l 3l ′ 3l ′′ nl ′′′ resonances associated with the 3p 1/2 → 3p 3/2 , 3s → 3p, 3p → 3d and 3s → 3d core excitations within the M-shell of the Fe XIV (1s 2 2s 2 2p 6 3s 2 3p) parent ion. This range also includes the 1s 2 2s 2 2p 6 3l 3l ′ 4l ′′ nl ′′′ resonances associated with 3s → 4l ′′ and 3p → 4l ′′ core excitations. We find that in the temperature range 2-14 eV, where Fe XIV is expected to form in a photoionized plasma, the Fe XIV recombination rate coefficient is orders of magnitude larger than previously calculated values.

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