Light propagation through multimode fibers suffers from spatial distortions that lead to a scrambled intensity profile. In previous work, the correction of such distortions using various wavefront control methods has been demonstrated in the continuous wave case. However, in the ultra-fast pulse regime, modal dispersion temporally broadens a pulse after propagation. Here, we present a method that compensates for spatial distortions and mitigates temporal broadening due to modal dispersion by a selective phase conjugation process in which only modes of similar group velocities are excited. The selectively excited modes are forced to follow certain paths through the multimode fiber and interfere constructively at the distal tip to form a focused spot with minimal temporal broadening. We demonstrate the delivery of focused 500 fs pulses through a 30 cm long step-index multimode fiber. The achieved pulse duration corresponds to approximately 1/30th of the duration obtained if modal dispersion was not controlled. Moreover, we measured a detailed two-dimensional map of the pulse duration at the output of the fiber and confirmed that the focused spot produces a twophoton absorption effect. This work opens new possibilities for ultra-thin multiphoton imaging through multimode fibers. References and links

In this work we demonstrate 3D imaging using two-photon excitation through a 20 cm long multimode optical fiber (MMF) of 350 µm diameter. The imaging principle is similar to single photon fluorescence through a MMF, except that a focused femtosecond pulse is delivered and scanned over the sample. In our approach, focusing and scanning through the fiber is accomplished by digital phase conjugation using mode selection by time gating with an ultra-fast reference pulse. The excited two-photon emission is collected through the same fiber. We demonstrate depth sectioning by scanning the focused pulse in a 3D volume over a sample consisting of fluorescent beads suspended in a polymer. The achieved resolution is 1 µm laterally and 15 µm axially. Scanning is performed over an 80x80 µm field of view. To our knowledge, this is the first demonstration of high-resolution three-dimensional imaging using two-photon fluorescence through a multimode fiber.

, "Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation," J. Abstract. We performed near-diffraction limited two-photon fluorescence (TPF) imaging through a lensless, multicore-fiber (MCF) endoscope utilizing digital phase conjugation. The phase conjugation technique is compatible with commercially available MCFs with high core density. We demonstrate focusing of ultrashort pulses through an MCF and show that the method allows for resolution that is not limited by the MCF core spacing. We constructed TPF images of fluorescent beads and cells by digital scanning of the phase-conjugated focus on the target object and collection of the emitted fluorescence through the MCF.

Ultrashort pulse ablation has become a useful tool for micromachining and biomedical surgical applications. Implementation of ultrashort pulse ablation in confined spaces has been limited by endoscopic delivery and focusing of a high peak power pulse. Here we demonstrate ultrashort pulse ablation through a thin multi-core fiber (MCF) using wavefront shaping, which allows for focusing and scanning the pulse without requiring distal end optics and enables a smaller ablation tool. The intensity necessary for ablation is significantly higher than for multiphoton imaging. We show that the ultimate limitations of the MCF based ablation are the nonlinear effects induced by the pulse in the MCFs cores. We characterize and compare the performance of two devices utilizing a different number of cores and demonstrate ultrashort pulse ablation on a thin film of gold.

Additive manufacturing, also known as 3D printing, is an advanced manufacturing technique that allows the fabrication of arbitrary macroscopic and microscopic objects. All 3D printing systems require large optical elements or nozzles in proximity to the built structure. This prevents their use in applications in which there is no direct access to the area where the objects have to be printed. Here, we demonstrate three-dimensional microfabrication based on two-photon polymerization (TPP) with sub diffraction-limited resolution through an ultra-thin, 50 mm long printing nozzle of 560 µm in diameter. Using wavefront shaping, femtosecond infrared pulses are focused and scanned through a multimode optical fiber (MMF) inside a photoresist that polymerizes via two-photon absorption. We show the construction of arbitrary 3D structures of 500 nm resolution on the other side of the fiber. To our knowledge, this is the first demonstration of microfabrication through a multimode optical fiber. Our work represents a new area which we refer to as endofabrication.