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The aim of this study was to compare the biological effects of helium and argon plasma in vitro. The cold plasma was generated using a device developed at the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod), which uses the principle of microwave ionization of the gas flow. We studied the crystallogenic activity of blood plasma. The description of dehydrated blood plasma samples was performed morphologically, using a system of visuametric parameters. Main morphometric parameters for analysis of blood plasma crystallization include crystallizability, structure index, facia destruction degree, and size of marginal zone. This study allowed us to establish that the effect of helium and argon in both free and ionized forms on the crystallogenic activity of blood varies significantly. The effect of cold plasma in general should be described as more favorable relative to the corresponding nonionized fluxes. At the same time, the most optimal nature of the reaction of the biological fluid was recorded when using a helium cold plasma. A specific feature of the helium flow is the suppression of the crystallogenic activity of the biological fluid, and the argon flow leads to its increase. Ionization of gases optimizes the nature of their influence, moreover, according to the modeling effect, the helium cold plasma is closest to the control sample.

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