Enhancement of HRQoL should represent the most critical goal of DM healthcare delivery. Effects of TM on HRQoL of diabetic patients should be studied further.

Objec ves: The correct seman cs management represents a fundamental requirement to create health informa on exchange (HIE) systems able to support clinical data sharing. A research is now underway to set up an infrastructure to aggregate data coming from health informa on systems, and it will be experimented to support regional HIE in Veneto region, Italy. Methods: In the fi rst period, the focus was on the seman cs management of Clinical Document Architecture Release 2 (CDA R2) laboratory reports, in which observa ons must be encoded using LOINC ® vocabulary. The exis ng components considered were the Laboratory Informa on Systems (LISs) of the local departments of the region (23 units) and the regional HIE. To manage the seman cs of the data, the design and the implementa on of a terminology service, the Health Terminology Service (HTS), compliant to the Common Terminology Service Release 2 (CTS2) standard was considered. Results: The HTS, formed by a set of web services, as CTS2 indicates, is the core of the proposed infrastructure. It is connected with an applica on that allows crea ng, dele ng, upda ng and managing the versioning of the maps between the laboratory observa ons and the LOINC ® en es. Conclusions: The adop on of CTS2 specifi ca on allows the HTS to support diff erent use cases, which are essen al to supports the clinical data sharing of the HIE content. During the development, the authors faced some problems that cause a delay in the implementa on of the solu on. The authors are s ll working to connect the HTS with the exis ng systems and to improve the solu on.

The service brought remarkable benefits at the organizational level. The reorganization of the processes and patient management leads to rationalization of both human and technological resources.

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