Background: The association between the use of antibiotics and bacterial resistance has obviously been established and it seems to be a significant problem for public health. It is clear that irrational use and high rates of antibiotic prescription are associated with increased bacterial resistance. As antibiotics are the class of drugs commonly prescribed in neonatal and Neonatal Intensive Care Unit (NICU) wards, neonates are at high risk of opportunistic or nosocomial infections due to prolonged hospitalization and immunosuppressed condition. Objectives: It is essential for antibiotic prescription patterns to be evaluated periodically for rational use. Therefore, the present study was carried out to identify the prescribing patterns of antibiotics in neonatal and NICU wards of 17 different Iranian hospitals. Methods: The study was done during 1 calendar week between January and February 2014. All in-patients admitted to the NICU and neonatal units of 17 Hospitals in 15 Iranian cities were included. Relevant data of all neonates receiving an antibiotic at 8 am on the day of the study was collected by trained members of the study team; age of the patients, type and number of administered antibiotics, route of administration, underlying disease, and indication for use were documented.

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Objective: Cardiovascular changes are related to some of epilepsy disorders such as seizures and breath holding. The study objective was to evaluate ECG findings in breath-holding and febrile convulsion compared to healthy individuals. Methodology: This Cross-sectional study was conducted on 270 children of 90 with febrile convulsion, 90 with breath-holding patients and 90 healthy children in 2019.  Electrocardiography parameters of; QT interval, dispersion QT, corrected QT and dispersion QTc measured for participants. Consent form was asked to be signed by the parents before the study execution. Data analysis done by SPSS 20.0 considering 0.05 as significant error. Results: Females were 46(51.1%), 38(42.2%) and 35(38.9%) in control, febrile convulsion and breath holding, respectively. QTc was normal in 97.8%, 76.7% and 71.1% of controls, febrile convulsion and breath holding respectively. A significant association observed between QTc measures in different groups (p<0.001). QTd was normal in 100.00%, 98.9% and 96.7% of controls, febrile convulsion and breath holding respectively with a non-significant association in groups of participants (p=0.196). QTcd was normal in 95.6%, 72.2% and 85.6% of controls, febrile convulsion and breath holding respectively with a significant association (p<0.001). Conclusion: Concluded that QTc was higher in breath-holding compared to febrile convulsion. QTcd was higher in febrile convulsion compared to breath-holding spells. Both were higher than controls QTd were higher significantly in the febrile convulsion compared to children with breath-holding spells. The results of the study suggested performing ECG for children who suffered from seizures or breath- holding spells to control their cardiac dysrhythmia.

Context: Hemolytic uremic syndrome (HUS), being more prevalent in infants and children, is recognized by a triad of acute kidney injury, microangiopathic hemolytic anemia, and thrombocytopenia. It is classified according to the underlying disorders, such as infection, systemic, metabolic disorder, or complement dysregulation. It has a high rate of morbidity and mortality. Many types of treatment, such as conservative management, plasma exchange, regular plasma infusion, and even a new expensive medication, "Ecluzimab", have been suggested. The aim of this systematic review is to estimate the incidence and prevalence of HUS (according to diarrhea positive or negative samples). In addition, the study will investigate the clinical presentation and the outcome of Iranian patients. Evidence Acquisition: The following data bases will be explored for articles published between years 1985 and 2016, PubMed, EM-BASE, OVID, SCOPUS, Web of Sciences, Google Scholar, Google, barakatkns.com, MagIran, SID, dociran, PDFiran, and ganj.irandoc. Besides, all online university databases will be searched for theses and abstracts of local or international congresses; a manual search will be performed to identify pertinent cross references. Systematic review or meta-analysis, longitudinal and cohort studies, crosssectional, case-control, and epidemiological studies will be included in this review. Relevant conference proceedings, theses or unpublished data will also be considered. The retrieved data should comprise of proportions, incidence, prevalence, geographical distribution, mortality and morbidity rates (i.e. dialysis and central nervous system involvement). A meta-analysis will be performed if 3 similar studies are found. If sufficient data is extracted, subgroup analysis will be performed for age, gender, acute kidney injury, dialysis, and death. Results:The results of the current study could have implications for health policies, practice, research, and medical education: The data could improve clinical and health care decisions, allow estimation of the number of patients that require new medication, and could direct future research design in this field.

Aims Bloody diarrhea is mainly caused by infectious agents (bacterial and parasitic), especially Shigella or Entamoeba species, and causes high mortality, especially in children. This study was conducted to compare the effects of azithromycin and cefixime on the treatment of dysentery in children referred to Zahedan University Medical Centers. Methods & Materials The participants of the present experimental study were 116 children aged 6 months to 5 years referred to Zahedan University Medical Centres diagnosed with dysentery by pediatricians with blood reported in their diarrhea stools. Dysentery was considered diarrhea with blood or diarrhea confirmed by stool tests. At the beginning of the study, patients’ names and contact numbers were obtained from patients’ families at the clinic. The blocking method with quadruple blocks was used for random allocation. The patients studied were in groups A and B. Group A received azithromycin for five days, with 12 mg/kg on the first day and 6 mg/kg over the next four days. Group B also received cefixime at 8 mg/kg daily for five days. Then, on the fifth day after the start of treatment, they were called to check the cases. Finally, the information was recorded and analysed. Findings In the present study, there was no significant difference between the two groups in terms of the average time of cessation of fever (P=0.887), the average time of cessation of blood excretion in feces (P=0.101), the average time of cessation of abdominal pain (P=0.133), and the average time of cessation of diarrhea (P=0.189). Conclusion In general, there was no clear clinical difference in the use of cefixime and azithromycin in the clinical recovery of children with dysentery. As a result, depending on the patient’s condition and the severity of the disease, it is recommended that the correct choice of these drugs be based on the physicians’ clinical experience and the patient’s condition.