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Carotid intima-media thickness (CIMT) is frequently utilized for detection of subclinical atherosclerosis. This study aims to investigate the association between the CIMT values and demographic characteristics, cardiovascular disease (CVD) risk factors, lipid biochemistry profiles, and high-sensitivity C-reactive protein (hs-CRP) levels among the Indonesian population. Subjects who had two or more CVD risk factors but were not receiving lipid-lowering therapy were recruited from six hospitals of Indonesia. Measurements of CIMT are obtained by ultrasonography of 12 sites within the common carotid artery. CVD risk factors, lipid and glucose profiles, and hs-CRP values were analyzed with respect to distribution of CIMT. The mean-max CIMT was 0.805 AE 0.190 mm (minimum, 0.268 mm; maximum, 1.652 mm) and the mean-mean CIMT was 0.614 AE 0.190 mm (minimum, 0.127 mm; maximum, 1.388 mm). Multivariate analyses confirmed an independent association between increasing CIMT and increasing age (regression coefficient ¼ 0.004; p ¼ 0.004). Our data show normative mean-mean CIMT data for Indonesian subjects with two or more CVD risk factors who are not receiving lipid-lowering therapy, which may guide CVD risk stratification of asymptomatic individuals in Indonesia.

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Methods: In this study, 61 patients were recruited from November 2021 -April 2022. Data were obtained from medical records as pre-and post-follow-up in 6 months period. Data pre-and post-follow-up were analyzed using the Wilcoxon and dependent T-test.Results: There were 64.52% patients with systolic hypertension. The median data of pre-and post-follow up showed that: HbA1C was 5.9% (range 3 -13) and 6.3% (range 5 -11) (p 0,959); BUN was 15,3 mg/dL (range 10 -32) and 14,8 mg/dL (range 13 -25) (p 0,638); serum creatinine was 0,8 mg/dL (range 0,4 -3,1) and 1,2 mg/dL (range 0,7 -2,6) (p 0,026); total cholesterol was 183 (range, 123 -300) and 219 (range 179 -231) (p 0,008); triglycerides was 133 (range 82 -326) and 159 (range 135 -394) (p 0,416); HDL was 40,65 SD±2 and 41 SD±2,3 (p 0,206); LDL was 117,5 SD±35 and 139,7 SD±20 (p 0,886); and urine microalbumin was 53 (range 5 -200) and 63,5 (range 5 -200) (p 0,721). Conclusion:Improvement in patients' outcomes has not been shown after Prolanis program. Further study with larger populations and more variables is needed.

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