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Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing ethanol gave N ′-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL1), which was characterized by NMR spectroscopy and single-crystal X-ray structure study. X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system. The reaction of HL1 with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental analysis, molar conductance, magnetic measurements, and infrared and electronic spectral studies. The compounds were screened for their in vitro cytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. Results showed that the compounds are potent against HL-60 cells with the IC50 value ≤5 μM, while some of the compounds were active against few studied Gram-positive bacteria.

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In this study, the antimicrobial activity of Pistacia terebinthus L. and Papaver rhoeas L. extracts were tested against some pathogen microorganisms. Leaves of the plant samples were freeze-dried and powdered. Three solvents were used for extraction. The agar well diffusion method is used for the antimicrobial activities of extracts. Six different bacteria, two yeasts, and two molds were used. The extracts of P. terebinthus L. was found more effect than P. rhoeas L. extracts against tested bacteria and fungi pathogens.

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