The concentrations of the salivary immune‐globulins IgA, IgG and IgM were determined with a solid phase radioimmunoassay in the unstimulated whole saliva of 21 patients with juvenile periodontitis (JP), their 27 healthy siblings and 17 healthy age‐matched controls.In the JP group the concentrations of IgA were increased, averaging 188 ± 32.5 (SE) mg/L as compared with the mean of 139 ± 21.2 mg/L in their healthy siblings and 130 ± 24.5 mg/L in the controls. An elevation was found in the amount of IgG in the JP patients: 45.6 ± 12.5 mg/L as compared with 18.1 ± 5.9 mg/L in the siblings and 21.0 ± 5.6 mg/L in the controls. The mean IgM was 22.5 ± 5.4 mg/L in the JP group, 13.3 ± 2.9 mg/L in the siblings and 8.7 ± 1.6 mg/L in the controls, indicating an increase of IgM in the JP group and the siblings.A significant difference was found in the mean IgM values in the juvenile periodontitis group when compared to the control group. (0.02 > P > 0.01).

The concentrations of total protein, albumin, IgA, IgG and IgM in human whole salivas were measured with a solid phase radioimmunoassay before and after physiological stimulation of salivary secretion. The geometric mean concentrations (mg/l) before stimulation were: total protein 1600, albumin 60, IgA 140, IgG 16 and IgM 4.1. Physiological stimulation of salivary secretion caused an increase of the total protein concentration to 2400 mg/l, had little effect on the concentrations of albumin and IgG, but lowered the concentrations of IgA and IgM to 56 mg/l and 1.7 mg/l, respectively. These findings indicate that a considerable portion of salivary IgA and IgM are produced locally depending on selective transport and that the release from local storage sites is not increased during stimulation as much as the total volume of the saliva.

— The concentrations of IgA, IgG and IgM in whole saliva of predentate babies, dentate adults, and edentulons old people, and the salivary IgG concentration of dentate old people, were determined using a solid phase radioimmunoassay. A highly significant difference in IgG concentratiorms was found between toothYess and dentate people. The average IgG concentrarion in the saliva of edentulous old people was 5.2 q/l, which was about 20° of that of dentate old people. The salivary IgG content of babies was only 1.7 q/I, which was in corxordance with the lovv postnatal serum IgG values. The salivary IgA level in this age group was also low. The edentulous old people tended to have decreased IgM values, and the predentate babies tended to have increased IgM values compared with the dentate adults.

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