The aim of the research was to study the relationship between the level of vaspin and the thickness of the intima-media of the carotid artery (CIMT), parameters of carbohydrate and lipid metabolism, functional state of the pancreas, markers of inflammation, and to create a mathematical model for the progression of atherosclerosis in patients with type 2 diabetes mellitus (DM-2) and chronic pancreatitis (CP). Materials and methods: Serum vaspin level in 114 people with DM-2 or CP and a combination of these diseases were obtained. The parameters of lipid and carbohydrate metabolism, inflammation and functional status of pancreas were studied. CIMT was measured by means of B-mode ultrasonography. The obtained data were processed by the methods of non-parametric statistics to study the dependence of the parameters on the group, questions of the statistical significance of differences between two unrelated groups, the tightness of the relationship between the analyzed parameters. Results: A statistically significant (p<0.05) increase in serum vaspin levels in patients with DM-2 compared with other studied groups was obtained. A reliable correlation between vaspin, carbohydrate metabolism and CIMT was obtained, and it appeared to be dependent on the presence of comorbid pathology. The value of vaspin / tumor necrosis factor-α (TNF-α), starting from which CIMT increase is considered present, was calculated. Conclusions: Undertaken study confirmed the positive connection of vaspin with insulin resistance markers, but also demonstrated that serum vaspin levels is positively associated with CIMT. A mathematical model for predicting the progression of atherosclerosis in patients with the studied pathology was developed. It was demonstrated that the Vaspin/TNF-α ratio can be used as a marker of early atherosclerotic lesion of vascular wall, indicating the role of vaspin in atherogenesis

Conclusions: Real-time VCI-A with a 4D electronic probe is an effective tool for imaging the fetal extremities in mid-trimester examinations and carries some advantages over conventional 2D sonography. Objectives: To assess the development in the diagnosis and outcome of prenatally diagnosed fetuses with talipes equinovarus (TEV). Methods: A retrospective evaluation of diagnosis, management and follow-up of cases of prenatally diagnosed fetuses with TEV in the years [2007][2008][2009][2010][2011][2012][2013][2014][2015][2016]. Results: We diagnosed 114 fetuses with TEV in our centre. The average age of women was 32.4 years. We found the outcome in case of 80 fetuses. There was a total of 48 fetuses with isolated TEV and of that, 32 fetuses were with associated anomalies. None of these malformations have been diagnosed in the first trimester. The diagnosis was set between 16 -32 weeks, with an average of 20.2 weeks. The ratio of male:female representation was 2.4:1. A positive family history of TEV has been present in 24 (30%) cases. Chromosomal aberration was diagnosed in 11 (14%) fetuses, false-positive diagnosis in 8 fetuses (10%). In 42 (75%) children, the conservative treatment has been followed up by surgical treatment, of that in 17 (30%) repeatedly. In the group of 48 fetuses with isolated TEV were diagnosed 29 fetuses with unilateral and 19 with bilateral TEV. One fetus died in utero. 47 children were born alive. In the case of isolated TEV there were postnatally diagnosed neurodevelopmental or structural abnormalities in 6 (13%) children. We diagnosed 32 fetuses with associated anomalies with TEV, with that 81% had the bilateral. In the group with associated congenital defect 22 (27.5%) women terminated the pregnancy. 9 children were born alive. Conclusions: In the case of isolated bilateral TEV, associated anomalies (T18, T21, Becker muscular dystrophy, FRAXA syndrome) were detected using AMC. Prenatally undiagnosed anomalies were VSD, anal atresia, hypotonia, Freeman Sheldon syndrome. AMC was used in case of 85 (75%) fetuses with TEV. Because of the possible associated anomalies, which cannot be diagnosed by ultrasound examination, the invasive procedure should be recommended to patients, especially in the case of bilateral TEV. EP07.10 EP08: FETAL STRUCTURAL ABNORMALITIES IEP08.01 Hemodynamic indices of mother-placenta-fetus system in pregnant at high risk of intrauterine infection L. Vygivska, E. Radzishevskaya, V. Kalnytska Kharkiv National Medical University, Kharkiv, UkraineObjectives: To assess hemodynamic criteria of mother-placenta-fetus system in pregnant at high risk of intrauterine fetal infection (IFI). Methods: The study involved Doppler examination of hemodynamics in mother-placenta-fetus system in 93 pregnant at high risk of IFI development with placental dysfunction. Screening for urogenital infections detected monoinfections in 26.9% and mixed bacterial-viral infections in 73.1% of patients. Blood flow velocity was studied in uterine arteries, umbilical artery and medial cerebral arte...

Introduction: Perinatal infections are an important issue in modern obstetrics, perinatal and pediatric care and one of the main causes of perinatal morbidity and mortality. The persistence of infection in the mother’s body can lead to an adverse outcome of pregnancy and childbirth, but it does not always mean the infection of the fetus and the development of an infectious disease. The presence of foci of infection in the body of a pregnant woman is only one of the reasons for the development of intrauterine infection. Dopplerometric study in IUI promotes identification of patients at risk of developmental retardation and helps to determine the initial signs of fetal distress. The aim: To study the features of hemodynamics of fetoplacental complex in pregnant with perinatal infections, depending on their implementation in newborns. Materials and methods: The study involved examination of 230 couples of pregnant-newborns, who were divided into clinical groups: Group I - 60 couples with viral infection; Group ІІ - 60 couples with bacterial infection; Group III - 60 couples with combined infection. Each clinical group was divided into 2 subgroups: with implementation of infection in newborns (1) and without it (0). Control group included 50 pregnant-newborns couples with physiological course of pregnancy and early neonatal period. Ultrasound (echographic and dopplerometric) study was performed according to the generally accepted technique on MINDRAY M7. The condition of the bloodstream was determined in the following vessels: umbilical artery, thoracic aorta, medial cerebral artery, uterine arteries. The resulting data was subject to statistical processing using the STATISTICA software. Results: Pregnant of the control and main groups underwent ultrasound somatogenic study with a syndromological analysis. Assessment of indices of RI and PI in the I-III clinical groups showed a tendency to increase. These values in the main group were significantly higher than the normative ones. More severe violations of the blood flow were observed in Group I and III. More pronounced changes in utero-placental-fetal blood flow were recorded in pregnant women with the implementation of infection. Peak systolic velocity in the medial cerebral artery was 1.3 times higher in Group II, 1.8 times higher in Group I and 1.6 times higher in Group III than in women with physiological pregnancy. Conclusions: Pregnant women of the main clinical group, in comparison with the normative indices of healthy pregnant, were found to have an increase in the indices of vascular resistance in the major vessels of the uterus-placental-fetal basin, which is likely due to the toxic effects of metabolic products of pathogens of infections that persist in the body on the endothelium of the blood vessels.

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