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In order to find suitable diagnostic procedures to use in an epidemiologic survey for the detection of animals infected with the bovine leukemia virus (BLV), the authors conducted an investigation on 262 Friesian dairy cattle. The results of hematologic, serologic, and electron microscopic examinations are reported. Evaluation of the results demonstrated the validity of the immunodiffusion and immunofluorescence tests and the opportunity for their use in conjunction with examination of the blood picture. From the data reported it would appear useful to extend the investigation to the herds without history of lymphosarcoma.

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