The Industrial Revolution Era 4.0 had a major impact on the life of a country. All nations are required to face this era with all the possibilities that exist. Indonesia wants to be able to compete globally, especially in the economic field. Millennial generation is considered capable of making this country more prosperous and advanced with all its characteristics, including santri. Millennial santri actually can also take part in economic growth in the Industrial Revolution 4.0 era, which is increasingly heavy competition. Through the power of MSMEs, santri and pesantren must have enormous potential in the government's big agenda, namely Indonesia 4.0. The potential for developing MSMEs can be felt more quickly if their development is supported by quality human resources and the provision of supporting facilities. Marketing training, working together with e-commerce platforms, internet procurement and supporting electronic devices, as well as network expansion to private companies and SOEs are steps that can be taken to encourage the growth of pesantren MSMEs. Through MSMEs, santri and pesantren are able to improve the country's economy but still uphold Islamic principles.

The discourse on interest can be said to be a "classic" problem both in the development of Islamic thought or in the history of human civilization. Because interest can not be separated from the economic activities of humanity. In Indonesia, interest has become transactions in the economic field in general. Until now interest collection still occurs in various commercial activities, both in the sale and purchase activities, accounts payable and other transactions. In Islamic teachings, economic activities carried out by humans have some rules and ethics or morality in Islamic law. However, the stipulation of interest as usury still needs an in-depth study, especially in terms of the history of legality stipulated in a fatwa in Indonesia.