Background: Black honey contains higher flavonoids, phenols, and minerals, which serves as antiinflammatory agents and promote faster wound healing. Purpose: This study aimed to determine the effectiveness of black honey on macrophage cells and blood vessels in rats’ wounds infected with Staphylococcus aureus. Methods: This was an experimental study with a post-test only control group design. This study involved 24 rats divided into 4 groups. The treatment was carried out for 5 days. The rats in the K1 group were wounded (cut) and given aquadest. The rats in the K2 group were wounded (cut), infected with Staphylococcus aureus, and given aquadest. The rats in the P1 group were wounded (cut), infected with Staphylococcus aureus, and treated with 2ml of black honey topically. The rats in the P2 group were wounded (cut), infected with Staphylococcus aureus, and treated with2ml of black honey orally. Observations were made histopathologicaly using hematoxylin-eosin (HE) staining by calculating the number of macrophage and blood vessels, and further using One-Way ANOVA. Result: The number of macrophages and blood vessels between groups was significantly different. The K2 group had the highest mean number of macrophage cells and blood vessels, and the K1 group was the least. The mean number of macrophage cells in the P1 group was more than the K1 group and less than the K2 and P2 groups, both significantly. Conclusion: Black honey was effective in reducing inflammation in wounds infected by Staphylococcus aureus.

Pendahuluan: Surgically induced necrotizing scleritis (SINS) merupakan komplikasi yang jarang dan terjadi setelah operasi okular. Sebagian besar kasus SINS berkaitan dengan penyakit autoimun sistemik. Skleritis setelah eksisi pterygium dapat terjadi akibat penggunaan iradiasi-?, mitomicin-C, dan kauterisasi berlebihan. Metode bare sclera pada eksisi pterygium dapat meningkatkan risiko terjadinya skleritis. Tujuan: Mendeskripsikan dua kasus SINS setelah eksisi pterygium dengan metode bare sclera. Presentasi kasus : Kasus pertama, pria berusia 44 tahun mengeluh terdapat bercak cokelat di area putih mata kirinya sejak 1 minggu sebelumnya. Pasien memiliki riwayat eksisi pterygium tanpa jahitan 3 minggu yang lalu. Tekanan intraokular sebesar 45 mmHg. Pasien diterapi dengan metilprednisolon oral, tetes mata fluorometolon, dan obat antiglakukoma. Kasus kedua, pria berusia 30 tahun mengeluh terdapat bercak cokelat pada area putih mata kanan sejak 1 minggu sebelumnya. Terdapat riwayat eksisi pterygium tanpa jahitan 3 minggu yang lalu. Pasien mendapat terapi metilpredinolon oral dan tetes mata prednisolon asetat. Kedua pasien menunjukkan perbaikan klinis setelah pemberian steroid. Kesimpulan: Etiologi infeksi perlu disingkirkan sebelum mendiagnosis SINS dengan terapi superinfeksi yang adekuat. Penanganan SINS berupa pemberian kortikosteroid dan agen imunosupresif. Tectonic grafting diperlukan untuk kasus berat.