The data were collected by a structured questionnaire including age, socioeconomic condition, gravida, para , blood pressure, BMI, FBS, PPBS & Family H/O diabetes mellitus. Patients suffering from shortened red blood cell life span, sickle cell disease or any other condition that could result in premature red blood cell death and longer red blood cell life span, such as vitamin B12 or folate deficiency were excluded. Total 110 pregnant women were included in this study. Among them 70 were considered as case (whose FBS &PPBS according to ADA criteria of FPG value of ³5.3mmol/l and the WHO criteria of a 2-h PPPG value of ³7.8mmol/l) and 40 were considered as control (whose FBS <5.3mmol/L & PPBS <7.8mmol/L). HbA 1c were measured in all sample. Results: Study showed that HbA 1c ( 6%) were more increased in GDM patients than that of the normal pregnancy ( (6.95±1.38% Vs 5.05 ±0.27 %, p<0.001).Result showed that percentage of raised plasma HbA 1C is more in GDM patients than that of the normal pregnancy (57.1%,P=<0.001).Pearson

Background : Decrease plasma High Density Lipoprotein Cholesterol (HDL-C) and increase triglyceride are major dyslipidemia in our country due to effects of carbohydrate rich diet. The relationship of low level of HDL -C in patient's of AMI and its extents of severity in coronary artery disease will be very important for future management as well as prevention of Coronary Artery Disease (CAD). Objective : The aim of this study is to assess the level of serum HDL-C in AMI patient and to assess whether low serum HDL-C level is an independent risk factor for acute ST elevation MI. Methods : It is a hospital based cross sectional observational study. 280 patients of acute STEMI who are admitted in coronary care unit selected for study. After estimation of serum lipid profile of these patients their serum level of HDL-C were used to detect the relationship between serum HDL-C and acute ST elevation MI. Results : In our study, among the case group (280 patiens) lipid profile estimation showed that about 64% patients of acute STEMI have low level of serum HDL-C. The other lipid fractions like triglyceride, low density lipoprotein cholesterol as well as total cholesterol were high in about 24%,39% & 44% but normal in 76%, 61% & 56% respectively. Conclusion : There is an independent inverse association of serum HDL-C in patients of acute STEMI and its an important indepedent risk factor.

Background: Patients with type II diabetes mellitus frequently have altered lipid profiles. Detection of serum high sensitivity C-reactive protein is associated with cardiovascular events in type II DM as the presence of subclinical inflammation. The study was undertaken to observe the fasting serum lipid profile level and its association with serum hs-CRP in type II DM. Materials and methods: A hospital-based observational study was carried out in the Outpatient Department of Endocrinology, Chittagong Medical College Hospital and Department of Biochemistry, Chittagong Medical College. By using non-probability consecutive sampling, a total of 176 participants were enrolled, with 126 type II DM and 50 in the control group. Plasma glucose and serum hs-CRP, fasting serum lipid profile was estimated. Results: The mean serum hs-CRP level in patients with type II DM (9.1 ± 0.36 mg/L) was significantly (p 0.0001) elevated as compared to control (4.3 ± 0.09 mg/L). The result showed an increase in serum total cholesterol, serum triglycerides, serum HDLC and serum LDL-C among the diabetic patients when compared with the healthy control group. Serum hs-CRP was significantly associated with serum TG and serum LDL-C in type II diabetics. Moreover, serum hs-CRP was found to have a significant positive correlation with serum LDL-C and serum TG. Only 77.78% of patients had increased LDL-C but altogether 85.71% of patients had increased serum hs-CRP levels. Conclusion: According to the findings of this study,increased serum hs-CRP was well associated and positively correlated with components of the fasting lipid profile, indicating early identification of cardiovascular risk among type II diabetics. Chatt Maa Shi Hosp Med Coll J; Vol.21 (2); July 2022; Page 35-39

Background: Anaemia is an almost invariable consequence of Chronic Kidney Disease. Among other causes, excessive haemolysis is also seen in advanced renal failure. The aim of this study is to observe the range of osmotic fragility of RBC in patients with chronic kidney disease and correlate the fragile states of RBC with different stages of chronic kidney disease. Materials and methods: It is a hospital based cross sectional observational study. 100 patients of diagnosed case of chronic kidney disease admitted in the Department of Nephrology, Chittagong Medical College Hospital were selected as cases and 100 apparently healthy persons, age and sex matched were selected as controls. Osmotic fragility of RBC was determined manually by traditional method in the department of Physiology, Chittagong Medical College, Chittagong. Data were analyzed by different statistical methods. Results: In our study, among the case group (100 patients), we found that 5.5% were on CKD stage III, 21% on stage IV, 23.5% on stage V. And 50% (100 apparently healthy subjects) were taken as control. Among the case group RBC osmotic fragility was decreased in 69% and remaining 31% was normal. Here the mean (±SD) of strength of NaCl solution were 0.30 (±0.05) and 0.44(±0.04)% in case and control group respectively where RBCs were partially hemolysed. The mean (±SD) of strength of NaCl Solution were 0.11 (±0.10) and 0.21(±0.09)% in case and control group respectively where RBCs were completely hemolysed. Again the mean (±SD) of strength of NaCl Solution were 0.33 (±0.03), 0.29 (±0.06) and 0.30(±0.05)% in CKD patients with stage III, IV and V respectively where RBCs were partially hemolysed. The mean (±SD) of strength of NaCl soluton were 0.14 (±0.09) and 0.08(±0.10)% and 0.12(±0.10)% in CKD patients with stage III, IV and V respectively where RBCs were completely hemolysed. Conclusion: The results of this study revealed that osmotic fragility status of RBC of CKD patients was significantly decreased which were inconsistent with other study. JCMCTA 2017 ; 28 (1) : 52 - 56

Overweight and obesity are the major health problem in both developed and devloping countries. Various lipid abnormalities are observed in overweight and obese population. The objective of the study to evaluate relationship between postprandial triglycerides with overweight and obesity.The present case control study was carried out in the Department of Biochemistry, Chittagong Medical College. Samples were collected from population of different area of Chittagong City Corporation of different occupations, age from 35-60 years. The data were collected by a structured questionaries. BMI was calculated by standardized protocol.Serum triglycerides was estimated at fasting, 2 hours postprandial and 4 hours postprandial condition and was analyzed in the semi auto analyzer.In the obtained results of this study the mean BMI of female was significantly (p <0.05) higher than that of male. Regarding fasting triglycerides there was a significant difference between values of serum triglycerides of cases and controls (p <0.001) . In respect of postprandial serum triglycerides value the mean value were significantly higher than of controls (p <0.001). Increased serum fasting TG was observed in 73% but increased postprandial serum triglycerides was observed in a higher score, ie, 92% cases in two hours postprandial and 81% cases in four hours postprandial.Study showed that post prandial hypertriglyceridemia was the common lipid abnormality in overweight and obese population. JCMCTA 2016 ; 27 (2) : 67 - 71