Highlights d E. piscicida reprograms its arginine metabolism for NLRP3 inflammasome evasion in BMDMs d E. piscicida infection increases host cytosolic arginine for polyamine synthesis d E. piscicida infection facilitates spermine accumulation in the cytosol of macrophages d Cytosolic spermine inhibits K + efflux-dependent NLRP3 inflammasome activation
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