-(Brazilian soybean Glycine max (L.) Merr. cultivars adapted to low latitude regions: seed composition and content of bioactive proteins). Among the goals of the Brazilian soybean improvement programmes, the breeding strategies for cultivars adapted to low latitudes have been included to extend crop areas and to increase production. Seeds of nine Brazilian soybean cultivars adapted to low latitudes were investigated regarding to their composition, and amino acid and antinutritional/ toxic protein contents. Protein (394.5 ± 13.1 to 445.3 ± 8.0 g kg flour) presented variations in their contents amongst the cultivars. Compared to other soybean cultivars, urease was higher, the acute toxicity lower and the lectin and trypsin inhibitor contents similar to data available. In general, soybean cultivars showed similar biochemical composition to those developed in different geographic regions. The relevance of these findings to the agronomic features and to choice of soybean cultivars to be used as food or feed is discussed.Key words -amino acid content, antinutritional factors, seed composition, soybean, toxicity RESUMO -(Cultivares brasileiras de soja Glycine max (L.) Merr. adaptadas ao cultivo em baixas latitudes: composição da semente e conteúdo de proteínas bioativas). Dentre os objetivos dos programas de melhoramento da soja no Brasil, está o desenvolvimento de estratégias para obtenção de cultivares adaptadas às regiões de baixas latitudes, visando a ampliação da área cultivada e o aumento da produção. Sementes de nove cultivares brasileiras de soja adaptadas a estas condições foram investigadas em relação à sua composição proximal e conteúdos de aminoácidos e proteínas tóxicas e/ou antinutricionais. Os conteúdos de proteína (394,5 ± 13,1 a 445,3 ± 8,0 g kg farinha). Comparados com outras cultivares de soja, os conteúdos de urease verificados foram superiores, a toxicidade aguda observada foi inferior e os conteúdos de lectina e inibidores de tripsina foram semelhantes aos resultados disponíveis na literatura. De um modo geral, as cultivares estudadas mostraram composição bioquímica similar àquela verificada para genótipos desenvolvidos em outras regiões geográficas. A relevância desses achados para as propriedades agronômicas e a seleção de cultivares de soja para a alimentação de seres humanos e animais são discutidas.Palavras-chave -composição química da semente, conteúdo de aminoácidos, fatores antinutricionais, soja, toxicidade
Treatment with HdCL reduced oxidative damage and modulated the expressions of CD4, CD8, FoxP3and HSP-60 in S180 solid tumor model, which can be associated to the presence of triterpenes, such as α-amyrin, β-amyrin and lupeol cinnamate. Present data emphasizes the importance of immune system in cancer and highlights the evaluation of the pharmacological properties of plants used by population as phytoterapics.
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