Cystic dystrophy of heterotopic pancreas is a rare condition that means cystic changes of normal pancreatic tissue, placed in unusual locations, commonly in the duodenal wall. We report a case of CDHP in stomach, histologically confirmed after surgery. We show the correlation between radiological and anatomopathological findings, and also review the current literature about reported cases of this exceptional disease.

Background: The role of IL-1β, PGE 2 and MMP-3 in the pathogenesis of periodontal disease is well researched. This study aimed to asses and compared the salivary IL-1β, PGE 2 and MMP-3 levels in patients with untreated chronic severe periodontitis and those treated with periodontal phase I therapy and periodontally healthy individuals as controls, in relationship to the presence of salivary anti-β 1 IgA. Methods: A total of 30 subjects participate in the study: 15 subjects had chronic severe periodontitis and 15 were healthy individuals used as a control. After saliva collection and its purification, we quantify by enzyme-linked immunosorbent assay (ELISA) procedure using as coating antigen a synthetic β 1 peptide with an amino acid sequence identical to the second extracellular loop of the human β 1 adrenoceptor (β 1 AR), the presence of anti β 1 AR antibody (IgA) in the saliva of patients and healthy individuals. Also, IL-1β, PGE 2 , nitrites and metalloproteinase 3 (MMP-3) were assessed using ELISA) assay. Results: Our data indicated that IL-1β, PGE 2 , nitrites and MMP-3 levels are elevated in the saliva of patients with untreated chronic severe periodontitis and were significantly higher than in healthy subjects. Also, the amounts of anti-β 1 IgA in the saliva was significantly higher compared with that of healthy individuals. After periodontal phase I therapy these levels of inflammatory biomarkers are significantly reduced but the titres of the antibody did not change, suggesting a close association between salivary IL-1β, PGE 2 , nitrites and MMP-3 and periodontitis without any changes in the levels of anti β 1 IgA. Conclusions: These results suggest that the abnormal amount of these cytokines and enzymes in saliva has potential monitoring applications as a risk marker of the disease progression but the raised levels of anti β 1 IgA present in the saliva of chronic severe periodontitis patient, are not directly associated with the course of the disease. Additional studies are needed to validate this assumption.

RESUMENEl proyecto de investigación y desarrollo del Picosatélite Académico UAPSAT, se orienta a que contemos con conocimientos propios, para estar presentes en la carrera espacial, en el ámbito universitario. Esta investigación y desarrollo efectuado en nuestro país, nos permite seguir una exhaustiva política de innovación tecnológica para desplegar proyectos de aplicación aeroespacial, inicialmente orientados a la detección de los fenómenos meteorológicos y su incidencia en la superficie terrestre.Desarrollar satélites de escala 1U (una unidad), usando la tecnología CUBESAT, con una masa de 1Kg y medidas de un cubo de 10 cm por arista, ello permitirá registrar temperaturas de la Tierra y de nuestro territorio y apoyar a instituciones nacionales e internacionales especializadas en este campo, con la finalidad de ubicar zonas vulnerables a desastres, debido a cambios climatológicos, cuyos resultados coadyuvarán a predecir y prevenir consecuencias fatales contra la población.El picosatélite tiene una carga útil cuya misión es estar enlazado, telemétricamente con la estación terrena ubicada a 12º latitud sur y 77º longitud oeste y a una altura aproximada de 800 km (Órbita Leo), con un periodo orbital de 90 minutos, y una frecuencia cada 12 horas; y permite comprobar el comportamiento del diseño electrónico de comunicación, orientación y estabilización, además verificar la aplicación de la tecnología y metodología utilizadas en la fabricación del satélite, capaces de desarrollar misiones científi-cas, que servirán al desarrollo de futuras investigaciones satelitales a nivel de Estado Peruano.

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e15229 Background: HPD is a new pattern of response consisting of accelerated tumor growth due to immunotherapy (5%-20% of pts on IO drugs). The tumor growth rate (TGR, Champiat et al.) estimates the differential increase in tumor volume over time, pre- and on IO drugs, to assess for HPD, but it is not easily calculated in practice. A comparison of the different methods to identify HPD is missing. Methods: Retrospective study of 182 consecutive pts treated in Phase 1 studies of IO drugs at START Madrid-CIOCC in 2017-8, comparing 3 HPD measurement criteria (Champiat, Matos -which does not use pre-baseline CT scans-, and Saâda-Bouzid). Cohen’s Kappa index was calculated as a measure of the agreement between the 3 methods, being those values closer to 1 the more concordant ones. Overall survival (OS) rates were calculated by Kaplan-Meier (p < 0.05 to be significant). Results: 99 (54%) of 182 pts had progressive disease at cycle 1 of treatment and in 62 (34%) pre-baseline CT scans were available to calculate TGR. The Champiat method identified 18 (9.9%) pts with HPD. Of 61 cases validated to comparison, the Matos criteria labeled 27 pts (14.8% of 182) with HPD, of whom only 10 pts coincided with those identified by Champiat with a low agreement (Kappa: 0.140, p:0.251). No significant differences in OS between pts with non-HPD vs HPD by Matos criteria were seen (p = 0.16). With Saâda-Bouzid method, of 59 cases validated to comparison, 17 pts (9.3% of 182) were labeled with HPD and 13 of them coincided with those identified by Champiat method with a high agreement (Kappa:0.706, p:0.000). Differences in OS between non-HPD vs HPD pts were statistically significant (p = 0.038). Conclusions: HPD might have a detrimental effect to 10% of pts on IO drugs, also in our series. Every effort should be done to obtain pre-baseline CT scans to identify HPD response to IO drugs, based on differential TGR. The use of Saâda-Bouzid method is preferred due to its practical application and its correlation with survival. [Table: see text]