Nephrotic syndrome (NS) is the most common glomerulopathy in childhood. The incidence of NS in the United States and United Kingdom is 2-7 new cases per 100,000 children per year, with a prevalence ranging from 16 cases per 100,000 children, and is found to be higher in developing countries. Nephrotic syndrome is a chronic disease that requires longterm monitoring because one of the complications that can be caused is cardiovascular complications caused by hyperlipidemia. High Sensitivity C-Reactive Protein (hs-CRP) can be used as a cardiovascular predictor in NS patients.Objective : To determine the differences in the value of hs-CRP in steroid sensitive nephrotic syndrome patients with steroid resistance.Methods : Case control design in 36 pediatric patients with nephrotic syndrome who came to the outpatient and inpatient unit of H. Adam Malik Hospital Medan from August 2020 to December 2020. Sampling using consecutive sampling technique, conducted interviews with parents, physical and laboratory examinations to confirm the diagnosis of steroid sensitive and steroid resistant nephrotic syndrome. An unpaired t-test and Mann-Whitney test were analyzed to assess the comparison between variables.Result : All NS patients were 36 subjects, 25 subjects (69.4%) were male and 11 subjects (30.5%) were female. The mean age of the study subjects for steroid sensitive NS patients was 8.4 (SD 4.8) years, whereas for steroid-resistant NS patients was 10.4 (SD 4.7) years. There was no significant difference between the hs-CRP value of steroid sensitive nephrotic syndrome patients with steroid resistance. Conclusion :There is no significant difference between the hs-CRP value of steroid sensitive nephrotic syndrome patients with steroid resistance.

Background Incidence of congenital heart disease (CHD) is about 0.8% of every child born. This heart defect is associated with dyslipidemia in children. Lipid profiles examination in patients with CHD can be used to determine risk factors for atherosclerosis. Objective To examine differences in lipid profiles in children with cyanotic and acyanotic CHD. Methods This was a cross-sectional study on 60 pediatric CHD patients at Haji Adam Malik Hospital, Medan, North Sumatera, from December 2020 to March 2021. Subjects were included by consecutive sampling. Data of patient’s age, gender, weight, height, complete blood count, blood glucose, and lipid profiles were recorded. Unpaired T-test analysis and Mann-Whitney test were then performed to analyze variables in cyanotic and acyanotic CHD patients. Results Of a total of 60 CHD children, 26 subjects had a diagnosis of cyanotic CHD and 34 subjects had a diagnosis of acyanotic CHD. The most common cause of cyanotic CHD was tetralogy of Fallot (76.9%), while the most common cause of acyanotic CHD were ventricular septal defect and patent ductus arteriosus (32.4% each). Analysis of lipid profiles on both groups revealed that low density lipoprotein (LDL) was significantly lower in the cyanotic group than in the acyanotic group (P<0.05). However, other lipid profile values, were not significantly different between groups. In addition, there was no significant difference in incidence of dyslipidemia between cyanotic and acyanotic CHD. Conclusion Low density lipoprotein is significantly lower in the cyanotic CHD group than in the acyanotic CHD group. But there are no significant differences in the other lipid profiles measurement and incidence of dyslipidemia between groups.