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Purpose: Purpose: Management of Fournier's Gangrene (FG) includes broad-spectrum antibiotics Management of Fournier's Gangrene (FG) includes broad-spectrum antibiotics with adequate surgical debridement, which should be performed within the first 24 hours with adequate surgical debridement, which should be performed within the first 24 hours of onset. However, this treatment may cause significant loss of tissue and may delay of onset. However, this treatment may cause significant loss of tissue and may delay healing with the presence of ischemia. Hyperbaric oxygen therapy (HBOT) has been healing with the presence of ischemia. Hyperbaric oxygen therapy (HBOT) has been proposed as adjunctive therapy to assist the healing process. However, its benefit is still proposed as adjunctive therapy to assist the healing process. However, its benefit is still debatable. Therefore, this systematic review and meta-analysis aimed to evaluate the debatable. Therefore, this systematic review and meta-analysis aimed to evaluate the effect of HBOT as an adjunct therapy for FG. effect of HBOT as an adjunct therapy for FG. Materials and Methods: Materials and Methods: This study complied with the Preferred Reporting Items forThis study complied with the Preferred Reporting Items for Systematic Reviews and Meta-analyses protocol to obtain studies investigating the Systematic Reviews and Meta-analyses protocol to obtain studies investigating the effect of HBOT on patients with FG. The search is systematically carried out on different effect of HBOT on patients with FG. The search is systematically carried out on different databases such as MEDLINE, Embase, and Scopus based on population, intervention, databases such as MEDLINE, Embase, and Scopus based on population, intervention, control, and outcomes criteria. A total of 10 articles were retrieved for qualitative and control, and outcomes criteria. A total of 10 articles were retrieved for qualitative and quantitative analysis. quantitative analysis. Results: Results: There was a significant difference in mortality as patients with FG who received There was a significant difference in mortality as patients with FG who received HBOT had a lower number of deaths compared to patients who received conventional HBOT had a lower number of deaths compared to patients who received conventional therapy (Odds Ratio 0.29; 95% CI 0.12 -0.69; p = 0.005). However, the mean length therapy (Odds Ratio 0.29; 95% CI 0.12 -0.69; p = 0.005). However, the mean length of stay with Mean Difference (MD) of -0.18 (95%