The occurrence of a macular hole due to posterior uveitis is infrequently reported. We report the evolution of three cases of macular holes secondary to posterior segment inflammation. A complete inflammatory and infectious assessment found one case of toxocariasis, one of sarcoidosis, and one of syphilis. After medical etiological treatment, macular hole closure was rapidly obtained in all the cases and confirmed by spectral domain optic coherence tomography, with visual acuity improvement. Fibrous scarring developed in two cases, and foveal photoreceptor complex normalization was observed in the sarcoidosis case. These observations demonstrate that macular holes secondary to posterior uveitis frequently resolve without surgical intervention and so could be underdiagnosed if the patient is not evaluated at the time of onset before spontaneous hole closure.

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Purpose Surgical treatment of epiretinal membrane (ERM) have been facilitated by use of dyes such as brilliant blue G (BBG) whose harmlessness by intravitrael injection have been fully reported. Methods We describe the case of a seventy‐two year old female patient addressed for surgical treatment of left idiopathic ERM that caused metamorphopsia and a decrease of visual acuity. Pars plana vitrectomy and ERM peeling staining with BBG was performed. Results During the procedure, an unusual complication occurs: intraretinal BBG infiltration. The area was limited (under a disc diameter) located in macular area, in temporal and superior to the fovea; the infiltration reached all retinal layers according to our OCT images. A defect in retina nerve fiber layer seems to be the origin of that staining. No damage in the field or in fluorescein and indocyanine angiography were observed. A progressive resorption of the staining appeared with atrophy of the inners retinal layers as aftereffect. Visual acuity reached 9/10 Pa2 a month and a half after the surgery. Conclusion In spite of the benefits of vital dyes in vitreoretinal surgery which are widely used, this case remains us the damage that can occur.