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Data management and processing to enable predictive analytics in cyber physical systems holds the promise of creating insight over underlying processes, discovering anomalous behaviours and predicting imminent failures threatening a normal and smooth production process. In this context, proactive strategies can be adopted, as enabled by predictive analytics. Predictive analytics in turn can make a shift in traditional maintenance approaches to more effective optimising their cost and transforming maintenance from a necessary evil to a strategic business factor. Empowered by the aforementioned points, this paper discusses a novel methodology for remaining useful life (RUL) estimation enabling predictive maintenance of industrial equipment using partial knowledge over its degradation function and the parameters that are affecting it. Moreover, the design and prototype implementation of a plug-n-play end-to-end cloud architecture, supporting predictive maintenance of industrial equipment is presented integrating the aforementioned concept as a service. This is achieved by integrating edge gateways, data stores at both the edge and the cloud, and various applications, such as predictive analytics, visualization and scheduling, integrated as services in the cloud system. The proposed approach has been implemented into a prototype and tested in an industrial use case related to the maintenance of a robotic arm. Obtained results show the effectiveness and the efficiency of the proposed methodology in supporting predictive analytics in the era of Industry 4.0.