The results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity. Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.

Composites of Keggin heteropolymetalates have been prepared and characterized by SEM, XPS, 31 P-magic angle spinning/nuclear magnetic resonance and differential scanning calorimetry. The phosphotungstic acid and phosphomolybdic acid form nanocomposites where the oxocluster structure is preserved and is highly dispersed over the material, probably inserted between the polymeric chains. Phosphovanadotungstic clusters suffer partial decomposition during composite formation, resulting in a biphasic microcomposite. The decomposition product, phosphotungstic acid presents surface segregation as shown by comparison of XPS and nuclear magnetic resonance results.

No abstract

No abstract