Polysaccharides are complex but essential compounds utilized in many areas such as biomaterials, drug delivery, cosmetics, food chemistry or renewable energy. Modifications and functionalizations of such polymers are often necessary to achieve molecular structures of interest. In this area, the emergence of the "click" chemistry concept, and particularly the copper-catalyzed version of the Huisgen 1,3-dipolar cycloaddition reaction between terminal acetylenes and azides, had an impact on the polysaccharides chemistry. The present review summarizes the contribution of "click" chemistry in the world of polysaccharides.
International audienceCyclodextrins are important building blocks in organic chemistry. This review deals with the role of click chemistry in this family of cyclic oligosaccharides, focusing on the different areas of chemistry, including chromatography, biological applications, the elaboration of superstructures, and metal detection, that benefit from this reaction. In this paper, attention is given to organic modifications by using functionalizations such as azidation and propargylation and to click chemistry grafting onto the two faces of cyclodextrins. Research papers where cyclodextrins are not directly involved in a click chemistry reaction are not considered
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.