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A backnard-elimination, multiple-regression analysis was used to determine which metedrological factors significantly explained the variation measured in concentrations of allergenic spore forms 1.5 m above ground level. Airspora were collected for three years (19761978) with volumetric samplers. Adequate moisture is probably the most important variable in spore production. In the imperfect fungi, once the spores are produced, release is often influenced by wind velocity. In the Ascomycetes, radiation, minimum humidity, changes in humidity, and minimum wind velocity were all directly correlated with airborne ascospores, while in the Basidiomycetes, precipitation was the most important variable directly correlated with basidiospores in the atmosphere.

We used Salmonella enteritidis serotype dublin strain SL1438, a nonreverting, aromatic-dependent, histidine-requiring mutant, as a recipient for a recombinant plasmid coding for production of the nontoxic B subunit of the heat-labile Escherichia coli enterotoxin. The S. enteritidis derivative EL23 produced heat-labile enterotoxin subunit B that was indistinguishable from heat-labile enterotoxin subunit B produced by strains of E. coli or Salmonella typhi harboring the same plasmid. Mice immunized orally with strain EL23 developed progressively increasing mucosal and serum antibody responses to both heat-labile enterotoxin subunit B and to the lipopolysaccharide of the vaccine strain. The mucosal antibody response was shown to be immunoglobulin A specific and to be capable of neutralizing the biological activities of both E. coli heat-labile enterotoxin and cholera enterotoxin in vitro.

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