Fertilized turkey eggs were injected with N-nitrosomopholine (1-10 mg/egg) or urethane (0.1-10 mg/egg) prior to or during the first hours of incubation. Four days prior to hatching, the experiments were terminated and the livers of the embryos removed. The hepatocarcinogens induced focally arranged hepatocytes with morphological and metabolic changes that were similar to preneoplastic foci observed in rodent studies in vivo. Foci with enlarged cells and excessive storage of glycogen as well as basophilic foci with small cells, low in glycogen content and with frequent mitotic figures were found. The in ovo transformation of embryonal hepatocytes may be a promising rapid model of hepatocarcinogenesis.

Clinical, post-mortem and histological findings are described for an African fish eagle (Hahiaeetus socifer), which was naturally infected with acid-fast organisms. In addition to this infection, there was an invasion of the air sacs and, to a lesser extent the lungs, by an Aspergillus sp. The predominant clinical sign was dyspnoea and there were acid-fast organisms in lesions in the liver and kidney in addition to the respiratory tract. 0N F.C.O./O.D.A. Secondment from the ARC.

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