Osteopetrosis is a collective term for a range of sclerosing bone diseases resulting from an absence or defective function of osteoclasts. The clinical expression is variable and includes skeletal, hematological and neurological manifestations. The common neurological manifestation includes cranial neuropathies involving optic, cochlear, facial and trigeminal nerves. Spastic quadriplegia occurring as a result of brain stem compression in osteopetrosis is uncommon. The association of Type 1 Arnold Chiari malformation with osteopetrosis resulting in brain stem compression syndrome is an extremely rare entity.

Primary mucosal malignant melanomas of sinonasal tract are uncommon tumors comprising 0.3-2% of all malignant melanomas and 4% of all head and Neck melanomas. We are reporting a rare case of mucosal malignant melanoma in a 45 year old female arising from nasopharynx which was excised completely by trans palatal approach followed by irradiation. This case is being reported because of its isolated involvement of nasopharynx, and early age of presentation.

Background: Malignant chondroid syringoma is one of the rarest clinical entities. It is a mixed cutaneous tumor with propensity for local invasion resulting in multiple local recurrences. Malignant chondroid syringoma has female predilection common in extremities. We are presenting this case in view of its rare presentation among the population, and unique clinical course. Case Report: A 38-year-old lady, known case of malignant chondroid syringoma of the left hand was treated for multiple local recurrences with excision, local radiation therapy and chemotherapy. She developed distant visceral metastasis over a span of 20 years after the primary diagnosis. Conclusion: Malignant chondroid syringoma has potential for both local recurrence and distant metastasis over a prolonged clinical course with on and off remission period. Because of its longer clinical course patients are recommended to be on regular follow up.