The recent publications by Creger2 have reported the a lithiation of aliphatic carboxylic acids using lithium diisopropylamide in tetrahydrofuran. The a-lithiated acid salts thus formed have been shown to react with alkyl halides and with epoxides.

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A series of des-His2 octa- and nonapeptide analogues of luliberin (luteinizing hormone-releasing hormone) with modifications in the 1 and 6 positions, and in some instances the 10 position, has been prepared. Some of these analogues are potent inhibitors of luliberin in vitro and in vivo. The use of ultraviolet absorption measurements for evaluating peptides containing tyrosine and tryptophan is described. An efficient synthesis of O-methyl-d-tyrosine is reported.

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