Patient-specific simulation plays an important role in cardiovascular disease research, diagnosis, surgical planning and medical device design, as well as education in cardiovascular biomechanics. simvascular is an open-source software package encompassing an entire cardiovascular modeling and simulation pipeline from image segmentation, three-dimensional (3D) solid modeling, and mesh generation, to patient-specific simulation and analysis. SimVascular is widely used for cardiovascular basic science and clinical research as well as education, following increased adoption by users and development of a GATEWAY web portal to facilitate educational access. Initial efforts of the project focused on replacing commercial packages with open-source alternatives and adding increased functionality for multiscale modeling, fluid-structure interaction (FSI), and solid modeling operations. In this paper, we introduce a major SimVascular (SV) release that includes a new graphical user interface (GUI) designed to improve user experience. Additional improvements include enhanced data/project management, interactive tools to facilitate user interaction, new boundary condition (BC) functionality, plug-in mechanism to increase modularity, a new 3D segmentation tool, and new computer-aided design (CAD)-based solid modeling capabilities. Here, we focus on major changes to the software platform and outline features added in this new release. We also briefly describe our recent experiences using SimVascular in the classroom for bioengineering education.

The objective of this work is to reduce the user effort required for 2D segmentation when building patient-specific cardiovascular models using the SimVascular cardiovascular modeling software package. The proposed method uses a fully convolutional neural network (FCNN) to generate 2D cardiovascular segmentations. Given vessel pathlines, the neural network generates 2D vessel enhancement images along the pathlines. Thereafter, vessel segmentations are extracted using the marching-squares algorithm, which are then used to construct 3D cardiovascular models. The neural network is trained using a novel loss function, tailored for partially labeled segmentation data. An automated quality control method is also developed, allowing promising segmentations to be selected. Compared with a threshold and level set algorithm, the FCNN method improved 2D segmentation accuracy across several metrics. The proposed quality control approach further improved the average DICE score by 25.8%. In tests with users of SimVascular, when using quality control, users accepted 80% of segmentations produced by the best performing FCNN. The FCNN cardiovascular model building method reduces the amount of manual segmentation effort required for patient-specific model construction, by as much as 73%. This leads to reduced turnaround time for cardiovascular simulations. While the method was used for cardiovascular model building, it is applicable to general tubular structures.

This paper presents a sampling-based motion planning algorithm for real-time and propellant-optimized autonomous spacecraft trajectory generation in near-circular orbits. Specifically, this paper leverages recent algorithmic advances in the field of robot motion planning to the problem of impulsively-actuated, propellant-optimized rendezvous and proximity operations under the Clohessy-Wiltshire-Hill (CWH) dynamics model. The approach calls upon a modified version of the Fast Marching Tree (FMT * ) algorithm to grow a set of feasible trajectories over a deterministic, low-dispersion set of sample points covering the free state space. To enforce safety, the tree is only grown over the subset of actively-safe samples, from which there exists a feasible one-burn collision avoidance maneuver that can safely circularize the spacecraft orbit along its coasting arc under a given set of potential thruster failures. Key features of the proposed algorithm include: (i) theoretical guarantees in terms of trajectory safety and performance, (ii) amenability to real-time implementation, and (iii) generality, in the sense that a large class of constraints can be handled directly. As a result, the proposed algorithm offers the potential for widespread application, ranging from on-orbit satellite servicing to orbital debris removal and autonomous inspection missions.

No abstract

Purpose-We accelerate a pathline-based cardiovascular model building method by training machine learning models to directly predict vessel lumen surface points from computed tomography (CT) and magnetic resonance (MR) medical image data. Methods-We formulate vessel lumen detection as a regression task using a polar coordiantes representation. Results-Neural networks trained with our regression formulation allow predictions to be made with significantly higher accuracy than existing methods that identify the vessel lumen through binary pixel classification. The regression formulation enables machine learning models to be trained end-to-end for vessel lumen detection without post-processing steps that reduce accuracy. Conclusion-By employing our models in a pathline-based cardiovascular model building pipeline we substantially reduce the manual segmentation effort required to build accurate cardiovascular models, and reduce the overall time required to perform patient-specific cardiovascular simulations. While our method is applied here for cardiovascular model building it is generally applicable to segmentation of tree-like and tubular structures from image data.