Hipertensi merupakan faktor penting sebagai pemicu penyakit tidak menular seperti penyakit kardiovaskuler yang lain. Kepatuhan minum obat bagi pasien penyakit kronis seperti  hipertensi sangat penting karena dengan minum obat secara teratur dapat mengontrol tekanan darah pasien.Penelitian ini bertujuan untuk menganalisis faktor apa saja yang mempengaruhi kepatuhan minum obat pasien hipertensi di puskesmas pringapus kabupaten semarang. Penelitian ini menggunakan desain deskriptif analitik menggunakan pendekatan cross sectional Study, Pengumpulan data dilakukan secara prospektif dengan cara memberikan kuisioner MMAS-8 kepada pasien yang memenuhi kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan dari 41 pasien yang mengisi kuisioner 15 pasien memiliki tingkat kepatuhan tinggi dan 26 pasien memiliki tingkat kepatuhan rendah. Hasil analisis hubungan antara kepatuhan dan faktor yang memungkinkan memberikan pengaruh adalah sebagai berikut kelamin = 0,15; umur = 0,56; pendidikan = 0,03; pekerjaan = 0,78; lama terapi = 0,42; jenis obat hipertensi yang didapatkan = 0,59 serta banayaknya obat yang dikonsumsi = 0,66. Dari hasil yang didapatkan dapat disimpulkan bahwa faktor pendidikan berpengaruh signifikan terhadap kepatuhan minum obat pasien hipertensi sedangkan faktor kelamin, umur, pekerjaan, lama terapi, jenis obat hipertensi yang didapatkan serta banayaknya obat yang dikonsumsi tidak  berpengaruh signifikan  terhadap kepatuhan minum obat pasien.Kata kunci : Kepatuhan, obat, hipertensi, prolanis, MMAS-8Hypertension is an important factor as a trigger for non-communicable diseases such as cardiovascular diseases. The adherence in using drugs for patients with chronic diseases such as hypertension is very important because taking medication regularly can control a patient's blood pressure. This study aims to analyze what factors influence compliance with taking medication for hypertensive patients at the pringapus health center in Semarang district. This study used a descriptive analytic design using a cross sectional study approach. Data collection was conducted prospectively by giving MMAS-8 questionnaire to patients who met the inclusion and exclusion criteria. The results showed that from 41 patients who filled out the questionnaire 15 patients had a high level of adherence and 26 patients had a low level of adherence. The results of the analysis of the relationship between adherence and the enabling factors for influencing were the following sex = 0.15; age = 0.56; education = 0.03; employment = 0.78; duration of therapy = 0.42; the type of hypertension drug obtained = 0.59 and the drug consumed is usually = 0.66. From the results obtained it can be concluded that educational factors have a significant effect on adherence to taking medication for hypertensive patients while genital factors, age, occupation, duration of therapy, types of hypertension drugs obtained and usually the drugs consumed do not significantly influence compliance with patient medication.Keywords: Compliance, medication, hypertension, prolanis, MMAS-8

Konsumsi makanan tinggi purin akan menyebabkan peningkatan kadar asam urat dalam darah. Akibat kadar  asam urat yang tinggi ( hiperurisemia) dan yang tidak terkontrol, akan menyebabkan gangguan pada organ tubuh sehingga timbul penyakit jantung, ginjal maupun Diabetes Mellitus. Allopurinol saat ini masih digunakan sebagai terapi asam urat / gout tetapi memiliki efek samping ruam, gangguan pencernaan, gangguan ginjal dan hati. Tujuan dari penelitian ini untuk mengkaji ekstrak labu kuning yang mengandung flavonoid dan terpenoid dapat digunakan sebagai terapi antihiperurisemia akibat adanya induksi pakan tinggi purin yaitu jus hati dan melinjo (1:1) selama 30 hari. Konsentrasi ekstrak yang digunakan 200 mg/KgBB, 400 mg/KgBB dan 600 mg/KgBB diberikan selama 7 hari dan dibuat sediaan sirup untuk memudahkan penggunaan.  Formulasi sirup diuji sifat fisik dan karakteristik berdasar SNI. Hasil penelitian, menunjukkan bahwa ELBK 600 mg/KgBB  memiliki aktivitas antihiperurisemia sebanding dengan Allopurinol (p value = 0,436 > 0,05), dan peningkatan konsentrasi ELBK memberikan aktivitas yang berbeda  terhadap penurunan kadar asam urat (p value= 0,00). Sediaan formulasi sirup belum memenuhi syarat mutu SNI karena pH masih asam, kadar gula dibawah 65%.Consumption of high purine feeds will cause an increase in uric acid levels in the blood. Due to high uric acid levels (hyperuricemia) and uncontrolled, it will cause disturbances in the body's organs, causing heart disease, kidney disease and Diabetes Mellitus. Allopurinol is used as a therapy for gout but has side effects of rashes, indigestion, kidney and liver disorders. The purpose of this study was to study pumpkin extract containing flavonoids and terpenoids which can be used as antihyperuricemia therapy due to the induction of high-purine feed, are chicken liver juice and melinjo (1: 1) for 30 days in Wistar rats. The concentration of the extract used was 200 mg / KgBW, 400 mg / KgBW and 600 mg / KgBW given for 7 days and a syrup formulation was made for ease of use. The syrup formulation with the ratio of PGA (7.5% and 10%) was tested for physical properties and characteristics based on the SNI quality requirements in the form of organoleptic, pH, specific gravity and viscosity. The results showed that ELBK 600 mg / KgBW had antihyperuricemic activity comparable to Allopurinol (p value = 0.436> 0.05), and increased ELBK concentrations gave different activities to decrease uric acid levels (p value = 0.00). Organoleptically in the form of shape, taste and smell, pumpkin syrup did not differ between groups due to the addition of PGA concentrations. Syrup have  pH 3.8 ± 0.011, BJ 1.260 ± 0.001. The viscosity of the syrup changed with the addition of the PGA concentration with a viscosity of F1 of 2.222 ± 0.001 cps and a viscosity of F 2 of 4.447 ± 0.001 cps. Pumpkin extract has activity in reducing uric acid levels and the syrup formulation does not meet the SNI quality requirements because the pH is still acidic, the sugar content is below 65%.