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Целью исследования было изучить встречаемость гипонатриемии у пациентов с хронической сердечной недостаточностью (ХСН) и СФВЛЖ. Результаты исследования показали, что гипонатриемия чаще ассоциируется с более тяжелым течением заболевания и неблагоприятным исходом у больных с сердечной недостаточностью (СН) и сохраненной фракцией выброса левого желудочка (СФВЛЖ) Ключевые слова: хроническая сердечная недостаточность, сохраненная фракция выброса, гипонатриемия, клиническое и прогностическое значение

To identify the most important clinical and laboratory markers that can be associated with an unfavorable course of HFpEF in patients with 2 type DM and without it. Methods. 108 diabetic and non-diabetic patients (57 males and 51 females) with HFpEF (EF ≥ 45%), NYHA Classes II and III were examined. Observation period was up to 30 months. The Galectin-3, TNF-alpha, NT-pro-BNP, CRP and insulin levels were measured in serum using ELISA according to manufacturer's instructions. For revealing associations between estimated endpoints occurrences and investigated factors a Cox proportional hazard analysis was performed. Discrimination refers to a model's ability to correctly distinguish 34 Iurii S. Rudyk et al. 2 classes of outcomes. All statistical tests were 2-tailed, and p<0.05 was considered statistically significant. Results. Cardiovascular events have been reported in 25 (23.1%) patients. Significant differences between two groups of patients were found in 6 parameters such as logHF duration, lnRSCS, logTriglyceride, logTNF-α, logGalectin-3 and logNT-pro-BNP. The most informative parameters for classification of patients in the groups of favorable or unfavorable HFpEF prognosis were level of Galectin-3 (p = 0.001), triglycerides (p = 0.020) and RSCS (p = 0.004). After calculating the coefficients for these parameters CLDF, they have been used for mathematical model creation. The mathematical model obtained using discriminant analysis allows with 84.4% accuracy to include patients in the group of favorable or unfavorable course of HFpEF. Conclusions. It was found, that increased levels of Galectin-3, TNF-α, triglycerides and NT-proBNP were associated with increased 30-months cumulative cardiovascular events number among diabetic and nondiabetic HFpEF patients. The most informative parameters for unfavorable course of HFpEF stratification was concentration of Galectin-3 (p <0.0001), triglycerides (p <0.01) and RSCS scores (p <0, 0,001).