How to achieve the sustainable and coordinated development of the ecological environment, the economy and tourism has already received much attention. In this paper, a comprehensive evaluation index system of the ecological environment, the economy and tourism is established, and the coupling degrees and coordination degrees of the three subsystems of 31 provinces in China from 2003 to 2017 are calculated. The results show that the average coupling degree and average coordination degree have fluctuating upward trends during the period of 2003-2017. According to the spatial distribution of the coupling degrees and coordination degrees, the coastal provinces and Chongqing, with their high ecological environment pressure and good economic development, have low coupling and extremely high coordination levels. The vast central and western provinces with good ecological environment protection and economic backwardness have high coupling and low coordination development level. From the perspective of coordinated development, only seven of the western provinces and three middle-eastern provinces possess basic coordinated development of the ecological environment, the economy and tourism. The remaining 21 provinces are over-utilizing or sacrificing their ecological environments, among which eleven eastern provinces have an advanced economy or advanced tourism and five southwestern provinces with high tourism resource endowments have an advanced tourism.

Compared with non-NPWT, NPWT significantly reduced the rates of dehiscence, seroma/hematoma, skin necrosis\blistering, and bleeding, but not surgical site infections.

Objectives: Caregiver-mediated intervention (CMI), based on parent skills training, is a family-mediated intervention model for children with neurodevelopmental disorders, in particular autism spectrum disorder. This study aimed to evaluate the effectiveness of CMI. Methods: Thirty-three children (aged 22–69 months from our department) and their caregivers participated in a two-week training course of ten 90-minute lessons. Caregivers were encouraged to try their best to apply intervention skills in both home routines and play routines to encourage the development of cognition, motion, social adaptability, and behavior of children. Demographic information, video-recorded data, and diagnostic scales were collected at two key time points: baseline and post-training (PT – within six months). Results: Three aspects were assessed – primary variables, secondary variables, and correlation analyses. Results showed an improvement in PT in (1) Adult/Child Interaction Fidelity Rating (P < 0.01) and (2) adaptability of Gesell Developmental Scale and stereotyped behaviors and limited interests of Autism Diagnostic Observation Schedule (P < 0.05, P < 0.01). Moreover, a negative correlation occurred between caregiver skill improvement and parent education (P < 0.05), but without correlations with other demographics. Conclusions: As an efficacious family intervention for both children and their caregivers, CMI is worth being generalized widely.