The reaction of Hg(TePh)2 with AgX (X = Cl, NO3) in the presence of PPh3 and PMePh2 in dimethylformamide (DMF) affords the cluster [Hg6Ag4(TePh)16] (1) at room temperature or [Hg6Ag4Te(TePh)14]2 (2) with heating. When Hg(TePh)2 is reacted with [Co(PPh3)2Cl2] or [Ni(PPh3)2Cl2], the clusters [Hg8Te(PhTe)12Cl4]Q [3; Q = [Co(DMF)6]2+ (3a), [Ni(DMF)6]2+ (3b)] are formed. The syntheses of 1 and 2 occur with the incorporation of AgI into the cluster, and the single-crystal analyses show that the two ternary clusters consist of Hg, Ag, and Te centers occupying well-defined positions. Compounds 3a and 3b do not show the incorporation of the metal into the cluster, but the CoII and NiII salts provide the Cl atom to generate the anionic cluster 3 stabilized by the [Co(DMF)6]2+ or [Ni(DMF)6]2+ ion.

Mycobacteriosis is a type of infection caused by rapidly growing mycobacteria (RGM), which can vary from localized illness, such as skin disease, to disseminated disease. Amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem and sulfamethoxazole are antimicrobial drugs chosen to treat such illnesses; however, not all patients obtain the cure. The reason why the treatment does not work for those patients is related to the fact that some clinical strains present resistance to the existing antimicrobial drugs; thereby, the research of new therapeutic approaches is extremely relevant. The coordination of antimicrobial drugs to metals is a promising alternative in the development of effective compounds against resistant microorganisms. Sulfonamides complexed with Au, Cd, Ag, Cu, and Hg have shown excellent activity against a variety of microorganisms. Considering the importance of fighting against infections associated with RGM, the objective of this study is to evaluate the antimycobacterial activity of metal complexes of sulfonamides against RGM. Complexed sulfonamides activity were individually tested and in association with trimethoprim. The minimum inhibitory concentration (MIC) and time-kill curve of compounds against the standard strains of RGM [Mycobacterium abscessus (ATCC 19977), Mycobacterium fortuitum (ATCC 6841) and Mycobacterium massiliense (ATCC 48898)] was determined. The interaction of sulfonamides with trimethoprim was defined by inhibitory concentration index fractional for each association. The results showed that sulfonamides complexed whit metals have outstanding antimicrobial activity when compared to free sulfamethoxazole, bactericidal activity and synergistic effect when combined with trimethoprim.

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Highlights Rapidly growing mycobacteria (RGM) causing infections by biofilm formation. Semi-quantitative method of biofilm formation was adapted for macrotechnics. Sulphonamides complexed with metals is a promising anti-adhesion agent. Sulphonamides complexed with metal is a possible inhibitor of signaling of biofilm formation.

Neste artigo estamos apresentando a síntese do composto [Cd 8 Cl 2 (µ 4 -Se) (SePh) 12 (PCy 3 ) 2 ]·2.5CH 3 OH pela reação de Cd(SePh) 2 com CdCl 2 e triciclohexilfosfina em metanol em um reator de aço inoxidável sob condições solvotérmicas a 130 °C. Esse composto corresponde ao último resultado de uma série sistemática de reações e visando ao crescimento de clusters moleculares a partir de Cd(SePh) 2 como reagente de partida. A importância desta síntese não está baseada somente nas propriedades do produto preparado, mas também no seu possível uso, por exemplo, no desenvolvimento de novas metodologias via estratégias "bottom up" para a obtenção de clusters a partir de uma mesma classe de reagentes -M(ER) 2 (M = metal, E = calcogênio, R = alquil ou aril). O composto apresentado neste artigo foi caracterizado por difração de raios X em monocristal, análise elementar, análise termogravimétrica e espectroscopia no UV-Vis. Estes últimos resultados foram correlacionados com dados calculados por DFT, teoria do funcional de densidade.In this article we present the synthesis of the compound [Cd 8 Cl 2 Se(SePh) 12 (PCy 3 ) 2 ]·2.5CH 3 OH by the reaction of Cd(SePh) 2 with CdCl 2 and PCy 3 in methanol in a stainless steel sealed reactor under solvothermal conditions at 130 °C. This compound represents the latest result of our systematic work on the growth of molecular clusters from Cd(SePh) 2 as starting material. Their importance is based not only on the properties of the new compounds, but also by their possible use, for example, in the development of new methods via a ''bottom up" strategy to obtain different clusters from single components like M(ER) 2 (M = metal, E = chalcogen, R = alkyl or aryl). The title compound was characterized by single crystal X-ray diffractometry, elemental analysis, thermogravimetrical analysis and the UV-Vis spectroscopy. These results were correlated with data calculated by DFT, density functional theory. Keywords: cadmium(II) complexes, selenium, tellurium, clusters IntroductionOrganylchalcogen groups bound to metal atoms to generate nanoclusters have become increasingly important due to their potential as semiconductors, among other materials and biological applications. [1][2][3][4] The unique optical and electronic properties inherent to these "quantumconfined particles" (quantum-dots) have been attributed to modifications of the electronic structure -depending upon the particle size -which lead to very different structures than those found in molecular solids or bulk materials. [5][6][7] Our search for new metalchalcogen-containing building blocks is of great interest for many reasons, principally because the variable size of the blocks produces tunable optoeletronic properties of the bulk products, [8][9][10] This emerging field -super lattices of crystalline chalcogenideslinks two traditional, but distinct, areas of research: chalcogenide clusters and reticular materials. [11][12][13][14][15][16][17][18][19] Some authors have proposed alternative ways for the development of metal-...