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The paper considers a synergistic analysis of the physical and physiological nature of electrical processes in the human heart, namely in the most important biosystem – the conduction nervous system of the heart (CNSH), in particular, the heart pacemaker. Currently, promising methods for studying CNSH as an active medium are being actively developed, using the foundations of nonlinear dynamics. Methods for describing active media are widely used in the study of the phenomena of the work of the heart pacemaker, where the active medium is represented as an ensemble of some elements that locally interact with each other. Self-organization in biological systems can be represented on the basis of a non-linear dynamic approach to the description of mechanisms in CNSH, namely, the consideration of P-cells of the pacemaker as a system of coupled non-linear oscillators. Such a synergistic method provides a real basis for modeling the processes of generation and propagation of nerve excitation in the heart using the Fermi–Pasta–Ulam (FPU) “return” theorem and the Kolmogorov–Arnold–Moser (KAM) theorem.