No abstract

No abstract

No abstract

No abstract

SummaryA swivel-tethering and jacket system was used in conjunction with vinyl patch electrodes and Holter recorders to obtain continuous ECG recordings in 12 rhesus monkeys on a long-term (12 day) study. Animals were custom-fitted with nylon mesh jackets that were connected to a swivel unit by a flexible, stainless steel tether. Lead wires from the chest electrodes passed through the tether to the electrical swivel apparatus located at the top of the cage. Wires from the upper part of the swivel were attached to a reel-to-reel Holter recorder. This technique was used to obtain 24-h continuous ECG recordings, which were later processed using a computer-assisted Holter analysis system. Keywords: Ambulatory monitoring; Electrocardiography; Macaca speciesNonhuman primates are frequently used in drug trials or studies involving compounds that may have cardiotoxic side effects. Electrocardiographs are often obtained to help evaluate the types and severity of any cardiac effects. Studies carried out over relatively sustained time-periods are generally performed on heavily sedated or chair-restrained animals.