Brain tumors are the most common solid tumors in childhood. Glioblastoma multiform (GBM) is the second most common primary brain tumor in adults. It usually affects the cerebral hemispheres of adults at the 6th or 7th decade of life. In comparison to adult population, GBM is rare in pediatrics and accounts for approximately 3% of all pediatric brain tumors. Pediatric glioblastoma was defined as patient age younger than 21 years at the time of craniotomy. The prognosis seems to be better in childhood. This report documented a GBM was located in the frontal lobe of a 9 year old girl who was diagnosed in Hamedan University of Medical Sciences in 2016. Magnetic resonance imaging (MRI) showed a huge well enhancing mass in left frontal lobe (47 ×35 mm ). This mass was surrounded by vasogenic edema and was extended to medial aspect of right frontal lobe through corpus callosum. The patient underwent a left frontal craniotomy, and gross total tumor removal was per¬formed. Pathology findings revealed neoplastic transformation of glial cells associated with vascular necrosis and neovascularization.

Can multisystem inflammatory syndrome in childhood (MIS-C) occur in the neonate associated with coronavirus disease (COVID-19)?Finding: A 9-day-old neonate infected with COVID-19 had fever, respiratory distress, and gastrointestinal symptoms suggestive of MIS-C. This neonate recovered after treatment with intravenous immunoglobulin (IVIG).Meaning: IVIG successfully treated a rare case of a 9-day-old neonate with COVID-19 and severe symptoms suggestive of MIS-C.

Introduction:Leiomyosarcoma is a malignant soft tissue tumor that can arise from any tissue containing smooth muscle. Leiomyosarcomas of the spermatic cord are rare tumors of non-testicular origin, which drain into the retroperitoneal lymph nodes and have been reported in less than 150 cases in the literature until now. Radical inguinal orchiectomy and high ligation of the cord is the standard primary surgical procedure in spermatic cord leiomyosarcoma.Case Presentation:Here we reported a 75-year-old man who presented with a painless lump in the right hemiscrotum. A right radical orchiectomy was performed. Histopathology confirmed a neoplastic tissue with mesenchymal origin in spermatic cord; further evaluation revealed a leiomyosarcoma of the spermatic cord. The patient was followed up for 1-year and shows no signs of recurrenceConclusions:Preoperative diagnosis of spermatic cord leiomyosarcma is difficult and commonly made by histological examination and immunochemical staining.