Field-effect
transistor (FET) devices based on conductive nanomaterials
have been used to develop biosensors. However, development of FET-based
biosensors that allow efficient stability, especially in the gas phase,
for obtaining reliable and reproducible responses remains a challenge.
In this study, we developed a nanodisc (ND)-functionalized bioelectronic
nose (NBN) based on a nickel (Ni)-decorated carboxylated polypyrrole
nanoparticle (cPPyNP)-FET that offers the detection of liquid and
gaseous cadaverine (CV). The TAAR13c, specifically binding to CV,
which is an indicator of food spoilage, was successfully constructed
in NDs. The NBN was fabricated by the oriented assembly of TAAR13c-embedded
NDs (T13NDs) onto the transistor with Ni/cPPyNPs. The NBN showed high
performance in selectivity and sensitivity for the detection of CV,
with excellent stability in both aqueous and gas phases. Moreover,
the NBN allowed efficient measurement of corrupted real-food samples.
It demonstrates the ND-based device can allow the practical biosensor
that provides high stability in the gas phase.
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