No abstract

The implant implanted into the body directly interacts with the bone tissue around the implant through its surface. The surface properties of the implant can affect the adhesion, proliferation, and differentiation of surrounding cells and ultimately determine the quality of osseointegration and the effect of implantation surgery. In this project, nano-hydroxyapatite (n-HA) and carbon fiber (CF) were added into the matrix, poly(ether-ether-ketone) (PEEK), forming the composite material HA/CF/PEEK. Since biologically active proteins and peptides can promote cell viability and proliferation, the osteogenic polypeptide sequence BEE1 was polymerized and grafted onto the surface of HA/CF/PEEK composites to generate HA/CF/PEEK-DPP and HA/CF/PEEK-DPP-BEE1 composites. The above materials were tested for physical characterization and in vitro cell activity by establishing a Beagle dog dentition defect model. HA/CF/PEEK type composites were selected for peri-implant bone defect repair and compared with titanium mesh alone or Bio-Gide membrane for alveolar bone defect repair. In the experiment, the HA/CF/PEEK material modified with osteogenic polypeptides changed in element composition, hydrophilicity, and surface morphology. in vitro cell assays detected that the surface of HA/CF/PEEK material modified with osteogenic polypeptides was more conducive to cell adhesion and proliferation and had no cytotoxicity. The peri-implant defect repair test showed that the HA/CF/PEEK-DPP-BEE1 composite material for alveolar bone repair in experimental dogs was better than that of titanium mesh or Bio-Gide membrane. Meanwhile, the mineralization speed and histomorphometry test at the bone defect further proved that this material could better promote bone neogenesis at the defect. Mineralization.

Dental graduates have a variety of career-path choices. After graduation, they may join private dental practice, government- or hospital-based dental care services, research groups, academia, business or industry. With globalization and frequent international exchange, dental graduates nowadays can explore careers outside their home country. However, dental education systems and job opportunities vary widely across different regions and countries. Diversity of accreditation in dental education, different licensure requirements, and lack of global competencies in dental care often limit the globalization, operation and survival of dental practice and education worldwide. The requirements for professional education and practice can be quite diverse, and these differences will be barriers to dental graduates seeking career development outside their home home country. Fresh dental graduates have minimal experience in job hunting. More specifically, they are unfamiliar with potential career paths. This paper was based on the 4th trilateral symposium 2022 organized by The University of Hong Kong, Tohoku University, and Fujian Medical University, which offered a lecture to discuss career paths for dental graduates in Hong Kong, Japan, and mainland China. The aim of this paper was to provide dentists, particularly fresh graduated dental students, with practical insight into different career paths in Hong Kong (Special Administrative Region of China, SAR), Japan and mainland China, and factors that may influence their career options. It assists dental students in exploring possibilities in dentistry and preparing for their career development after graduation from dental school.