Despite regulation of the reactive oxygen species (ROS) level is an intelligent strategy for cancer therapy, the therapeutic effects of ROS-mediated therapy (including photodynamic therapy (PDT) and chemodynamic therapy (CDT)) are limited by oxygen reliance, inherent flaws of traditional photosensitizers, and strict reaction conditions of effective Fenton reaction. Herein, we reported biocompatible copper ferrite nanospheres (CFNs) with enhanced ROS production under irradiation with a 650 nm laser through direct electron transfer and photoenhanced Fenton reaction and high photothermal conversion efficiency upon exposure to an 808 nm laser, exhibiting a considerable improved synergistic treatment effect. Importantly, by exploiting the properties of O generation and glutathione (GSH) depletion of CFNs, CFNs relieve the hypoxia and antioxidant capability of the tumor, achieving photoenhanced CDT and improved PDT. The high relaxivity of 468.06 mM s enables CFNs to act as an outstanding contrast agent for MRI in vitro and in vivo. These findings certify the potential of such "all in one" nanotheranostic agent integrated PDT, photoenhanced CDT, photothermal therapy (PTT), and MRI imaging capabilities along with modulating the tumor microenvironment function in theranostics of cancer.

No abstract

Vanadium pentoxide (V2O5) has attracted much attention for energy storage application because of its high Faradaic activity and stable crystal structure, which make it a promising electrode material for supercapacitors. However, the low electronic conductivity and small lithium-ion diffusion coefficient of V2O5 limit its practical applications. To overcome these limitations, a facile and efficient method is here demonstrated for the fabrication of V2O5/reduced graphene oxide (rGO) nanocomposites as electrode materials for supercapacitors. With this method, the reduction of graphene oxide can be achieved in a cost-effective and environmentally friendly solvent, without the addition of any other toxic reducing agent. Importantly, this solvent can control the formation of the uniform rodlike V2O5 nanocrystals on the surface of rGO. Compared to pure V2O5 microspheres, the V2O5/rGO nanocomposites exhibited a higher specific capacitance of 537 F g(-1) at a current density of 1 A g(-1) in neutral aqueous electrolytes, a higher energy density of 74.58 Wh kg(-1) at a power density of 500 W kg(-1), and better stability even after 1000 charge/discharge cycles. Their excellent performances can be attributed to the synergistic effect of rGO and rodlike V2O5 nanocrystals. Such impressive results may promote new opportunities for these electrode materials in high-energy-density storage systems.

No abstract

The integration of different imaging functions into an ultrasmall nanoplatform with excellent biocompatibility and metabolic performance to fabricate multimodal imaging probes has been a tremendous challenge. Herein, a novel kind of gadolinium-and ytterbium-doped carbon dots (Gd/Yb@ CDs) with diameter of 5.26 ± 0.93 nm was obtained by the convenient one-step hydrothermal process for magnetic resonance imaging (MRI), X-ray computed tomography (CT), and fluorescent imaging (FI). The obtained Gd/Yb@ CDs exhibited not only the excitation-dependent emission and superhigh photostability but also higher longitudinal relaxivity (r 1 = 6.65 mM −1 s −1 ) and excellent X-ray absorption performance (45.43 HU L g −1 ). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, tissue section assessment, and body weight investigation shed light on the superior biocompatibility of these Gd/Yb@CDs. MRI/CT imaging demonstrated these multimodal nanoprobes could give rise to obviously enhanced contrast effect on the xenografted tumor model. Furthermore, biodistribution analysis demonstrated that these nanoprobes could be easily removed from the mice through the kidney elimination pathway. Therefore, the present Gd/Yb@CDs could be served as promising MRI/CT/FI multimodal nanoprobes to provide more accurate and comprehensive diagnosis information.