Olanzapine is an atypical antipsychotic with proven efficacy in the treatment of schizophrenia and bipolar disorder. This molecule is known for its metabolic side effects, but it is considered the safest with regard to haematological toxicity. The case of our 28 year old patient, who has been followed anarchically for 5 years for schizophrenia and who presented a thrombocytopenia of 99,000/mm3 within a week of being put on olanzapine without any other associated signs, is one of nine cases published in the literature illustrating this association which is rare but encourages clinicians to institute close haematological monitoring to prevent any life threatening effects.

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by persistent impairment in reciprocal communication and social interactions and a restricted repetitive pattern of behaviors, interests, or activities. Tourette syndrome (TS) is a neurological disorder with a genetic component characterized by involuntary, sudden, brief and intermittent tics, resulting in movements (motor tics) or vocalizations (sound tics). Although a differential diagnosis of the two conditions can often be made, there are also cases of comorbidity in the same patient. Recently, a number of studies have attempted to explore modifiable environmental risk factors for ASD and TS. Among these risk factors is in vitro fertilization, an assisted reproduction technique, which has become increasingly common. The aim of our work is to highlight via a clinical case and a review of the literature on the association between the use of in vitro fertilization, the risk of autism spectrum disorder and Tourette syndrome. Compared to spontaneous conception, in vitro fertilization treatment as a whole was associated with a small but statistically significantly increased risk of autism spectrum disorder and Tourette syndrome.

IntroductionAlcohol use disorder is a real public health problem in the world, it consists of a pathological mode of consumption which is characterized by a loss of control and craving. Depressive disorder and alcohol use disorder are among the most frequent mental pathologies and are often associated.The links between these two disorders can be of several types: Alcohol Induced Depressive Disorders, Primary Depressive Disorders and Secondary Alcohol Dependence. They can also have two-way relationships or be favored by common factors.ObjectivesThe objective of our work is to analyze the causal links between alcohol use disorder and depression.Methodsprovide an update via two clinical vignettes and a review of the literature the relationship between alcohol use disorder and depressionResults The causal relationships between alcohol dependence and psychiatric disorders can be of several types which are not mutually exclusive: primary alcohol dependence, secondary psychiatric disorders, induced by alcohol. This is the case for the majority of depressive disorders encountered in alcohol-dependent patients; primary psychiatric disorders and secondary alcohol dependence; alcohol dependence and anxiety and/or depressive disorders are favored by common factors, in particular personality disorders, encountered in approximately 40% of alcohol-dependent patients. Whatever the direction of causation, alcohol dependence and psychiatric disorders worsen each other over time.Depression and alcohol use disorder are among the most frequent mental pathologies and are often associated.The optimal management of patients with dual diagnosis is so-called “integrated” management, simultaneously combining alcohol and psychiatric therapeutic approaches.ConclusionsAlcohol consumption impairs the prognosis of depression, increases the risk of suicide, impairs social functioning and increases recourse to the healthcare system.The optimal management of patients with dual diagnosis is so-called “integrated” management. Psychotherapeutic (individual and systemic), drug and psychosocial approaches would be necessary to maximize therapeutic success.Disclosure of InterestNone Declared

IntroductionSchizophrenia is a severe mental illness but especially important in terms of its impact on the subject. The stigmatization of these patients is major, leading to a significant decrease in their quality of life. This is partly due to the media coverage of the rare cases of hetero-aggression.The aggressiveness of schizophrenic subjects remains poorly known and little studied.ObjectivesThe objectives of our study are to determine whether the prescription of second-generation antipsychotics is associated with lower levels of aggression than the prescription of first-generation antipsychotics and to identify aggravating factors.MethodsMaterials and methods: We used an anonymous questionnaire based on, in addition to individual status and conditions, a self-administered questionnaire to assess the degree of aggression (the Buss and Perry Aggression Questionnaire (BPAQ)).ResultsOur study demonstrated superiority of second-generation antipsychotics in preventing aggression in subjects with schizophrenia, as well as an association between increased aggression and low insight, low compliance and low social support. In addition, younger age, male gender, and lower education were associated with increased aggression.ConclusionsThe prevention of aggression would then begin with the management of psychotic symptoms and comorbid disorders, as well as work on the compliance and insight of these patients. However, the aggressive dimension persists in some of them.Disclosure of InterestNone Declared

IntroductionHabituellement, nous voyons dans la consultation psychiatrique des patients épileptiques pour des plaintes psychologiques. Souvent pour un trouble anxieux ou dépressif. Dans d’autres cas, nous prenons en charge des patients psychiatriques atteints d’épilepsie.ObjectivesL’objectif de notre travail est d’étudier la prévalence de la comorbidité psychiatrique dans une population de patients épileptiques.MethodsNous avons mené une étude transversale auprès de la consultation de l’hopital ar-razi de salé, à l’aide d’un questionnaire et d’échelles d’évaluation préétablies : le MINI (mini entretien neuropsychiatrique international), l’inventaire de la dépression de Beck, et Échelle d’anxiété de Hamilton.Results55 patients ont répondu aux critères d’inclusion. L’âge moyen de nos patients est de 25,9 ans. Le sex-ratio F/H est de 1,6. Plus de la moitié de nos patients sont célibataires (78%). Seuls 21 % des patients ont une activité professionnelle régulière. La prévalence des troubles psychiatriques dans notre étude est de 66,6%. L’anxiété est retrouvée dans 68,2 % des cas, alors que la dépression est évaluée à 58,9 % des cas dont 23,7 % ont une dépression sévère qu’il faut traiter, avec une prédominance du sexe féminin (66,8 %).ConclusionsDans notre étude, l’ anxiété et la dépression sont les troubles psychiatriques les plus rapportés en cas d’épilepsie. Ils doivent être systématiquement recherchés pour tout épileptique et traités pour améliorer la qualité de vie des patients.Disclosure of InterestNone Declared