Olanzapine is an atypical antipsychotic with proven efficacy in the treatment of schizophrenia and bipolar disorder. This molecule is known for its metabolic side effects, but it is considered the safest with regard to haematological toxicity. The case of our 28 year old patient, who has been followed anarchically for 5 years for schizophrenia and who presented a thrombocytopenia of 99,000/mm3 within a week of being put on olanzapine without any other associated signs, is one of nine cases published in the literature illustrating this association which is rare but encourages clinicians to institute close haematological monitoring to prevent any life threatening effects.

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by persistent impairment in reciprocal communication and social interactions and a restricted repetitive pattern of behaviors, interests, or activities. Tourette syndrome (TS) is a neurological disorder with a genetic component characterized by involuntary, sudden, brief and intermittent tics, resulting in movements (motor tics) or vocalizations (sound tics). Although a differential diagnosis of the two conditions can often be made, there are also cases of comorbidity in the same patient. Recently, a number of studies have attempted to explore modifiable environmental risk factors for ASD and TS. Among these risk factors is in vitro fertilization, an assisted reproduction technique, which has become increasingly common. The aim of our work is to highlight via a clinical case and a review of the literature on the association between the use of in vitro fertilization, the risk of autism spectrum disorder and Tourette syndrome. Compared to spontaneous conception, in vitro fertilization treatment as a whole was associated with a small but statistically significantly increased risk of autism spectrum disorder and Tourette syndrome.

IntroductionAlcohol use disorder is a real public health problem in the world, it consists of a pathological mode of consumption which is characterized by a loss of control and craving. Depressive disorder and alcohol use disorder are among the most frequent mental pathologies and are often associated.The links between these two disorders can be of several types: Alcohol Induced Depressive Disorders, Primary Depressive Disorders and Secondary Alcohol Dependence. They can also have two-way relationships or be favored by common factors.ObjectivesThe objective of our work is to analyze the causal links between alcohol use disorder and depression.Methodsprovide an update via two clinical vignettes and a review of the literature the relationship between alcohol use disorder and depressionResults The causal relationships between alcohol dependence and psychiatric disorders can be of several types which are not mutually exclusive: primary alcohol dependence, secondary psychiatric disorders, induced by alcohol. This is the case for the majority of depressive disorders encountered in alcohol-dependent patients; primary psychiatric disorders and secondary alcohol dependence; alcohol dependence and anxiety and/or depressive disorders are favored by common factors, in particular personality disorders, encountered in approximately 40% of alcohol-dependent patients. Whatever the direction of causation, alcohol dependence and psychiatric disorders worsen each other over time.Depression and alcohol use disorder are among the most frequent mental pathologies and are often associated.The optimal management of patients with dual diagnosis is so-called “integrated” management, simultaneously combining alcohol and psychiatric therapeutic approaches.ConclusionsAlcohol consumption impairs the prognosis of depression, increases the risk of suicide, impairs social functioning and increases recourse to the healthcare system.The optimal management of patients with dual diagnosis is so-called “integrated” management. Psychotherapeutic (individual and systemic), drug and psychosocial approaches would be necessary to maximize therapeutic success.Disclosure of InterestNone Declared

IntroductionIn terms of care, family has a major role to play in the evolution of psychiatric illness.Our aim in this work is to determine the family experience during the hospitalization of their sibling in the emergency room of the psychiatric university hospital Ar-Razi in Salé.ObjectivesOur aim in this work is to determine the family experience during the hospitalization of their sibling in the emergency room of the psychiatric university hospital Ar-Razi in Salé.MethodsOur work was carried out with families of patients admitted to the emergency department of the psychiatric university hospital Ar-Razi in Salé.The data collection was carried out with the help of a questionnaire including several items.ResultsSixty-five family members were included in this study. Their relatives hospitalized in the psychiatric emergency department were male in 70% of cases with an average age of 32.4 years.-In 76% of the cases, the family member interviewed was the one who requested hospitalization;-55% of those interviewed were parents.The analysis of relatives’ feelings during the hospitalization showed:-Feelings of guilt were related to feelings of fear of exclusion and worries.-Feelings of fear and exclusion were mostly expressed by mothers of patients hospitalized for the first timeAt the end of the hospitalisation, 90% expressed relief, and 85% of family members were satisfied with their relative’s stay in the psychiatric emergency department.ConclusionsRecognizing families as units of care and understanding their situation and experiences facilitates the post-hospitalization care process. A well-informed family about mental illness and the types of therapeutic treatments available helps optimize the treatment.Disclosure of InterestNone Declared

IntroductionThe comorbidity between depressive disorders and addiction is far from being random. Through substances, users try to ameliorate their feelings of sadness, reduce present anxiety. The phenomena of tolerance and dependence quickly worsen the situation, and make any attempt at withdrawal more difficult.ObjectivesThe objective of this study is to analyze the addictive behavior in patients diagnosed with depressive disorder.MethodsThis is a retrospective descriptive study carried out by analyzing hospitalization records in the addictology department of the psychiatric university hospital Ar-Razi in Salé over a period of one year (from August 2020 to August 2021). The diagnoses are established according to the DSM 5 diagnostic criteria.ResultsOf 141 patient records initially entered, nine records were not usable and 54 patients had a diagnosis of depressive disorder constituting 40.9% of admissions to the service. The average age was 37.9 years (16; 69).Among our depressed and substance-using patients, the most frequent comorbidity was personality disorders (29.6%) followed by anxiety disorders (11.1% of cases). Thirty-five percent of patients reported at least one suicide attempt in the past and 11.1% had experienced sexual abuse.The average age of onset of addiction in our sample was 17.8 years (11; 31). The most used substance was tobacco (n=44) followed by alcohol (n=43), cannabis and then benzodiazepines.ConclusionsThe relationship between depression and substance use remains complex. Although depressed patients often turn to drugs in search of a state of well-being, withdrawal from these substances can also aggravate or cause the depression.Disclosure of InterestNone Declared