Olanzapine is an atypical antipsychotic with proven efficacy in the treatment of schizophrenia and bipolar disorder. This molecule is known for its metabolic side effects, but it is considered the safest with regard to haematological toxicity. The case of our 28 year old patient, who has been followed anarchically for 5 years for schizophrenia and who presented a thrombocytopenia of 99,000/mm3 within a week of being put on olanzapine without any other associated signs, is one of nine cases published in the literature illustrating this association which is rare but encourages clinicians to institute close haematological monitoring to prevent any life threatening effects.

IntroductionAntipsychotic drugs are widely prescribed for schizophrenia and other mental disorders. They are critical in the pharmacological management of severe psychotic disorder.The adverse effects of antipsychotics are common, with a potential negative impact on adherence and engagement. Despite this, the scientific study of the prevalence of adverse antipsychotic effects is a neglected area.ObjectivesWe aim to identify the prevalence of nine clinically important categories of antipsychotic adverse effects, namely: extrapyramidal symptoms; sedation; weight gain; type II diabetes; hyperprolactinaemia; metabolic syndrome, dyslipidaemia; sexual dysfunction; and cardiovascular effectsMethodsThis is a prospective, observational, cross-sectional study, carried out in Ar-razi hospital in Salé evaluating side effects in patients hospitalized and treated with antipsychotics within 3 months.ResultsIn total, antipsychotic polypharmacy was associated with increased frequency of adverse effects, and a longer duration of treatment is associated with greater severity; clozapine was more strongly associated with metabolic disturbance than other antipsychotics in three studies and olanzapine was associated with the most weight gain in three studies; hyperprolactinemia was more common in women than men, but more men noted sexual dysfunction than women;ConclusionsAntipsychotic adverse effects are diverse and frequently experienced, but are not often systematically assessed. There is a need for further scientific study concerning the management of these side effects.Disclosure of InterestNone Declared