The blazar 3C 279, one of the brightest identified extragalactic objects in the γ-ray sky, underwent a large (factor of ∼10 in amplitude) flare in γ-rays towards the end of a 3-week pointing by CGRO, in 1996 January-February. The flare peak represents the highest γ-ray intensity ever recorded for this object. During the high state, extremely rapid γ-ray variability was seen, including an increase of a factor of 2.6 in ∼8 hr, which strengthens the case for relativistic beaming. Coordinated multifrequency observations were carried out with RXTE, ASCA, ROSAT and IUE and from many ground-based observatories, covering most accessible wavelengths. The well-sampled, simultaneous RXTE light curve shows an outburst of lower amplitude (factor of ≃3) well correlated with the γ-ray flare without any lag larger than the temporal resolution of ∼1 day. The optical-UV light curves, which are not well sampled during the high energy flare, exhibit more modest variations (factor of ∼2) and a lower degree of correlation. The flux at millimetric wavelengths was near an historical maximum during the γ-ray flare peak and there is a suggestion of a correlated decay. We present simultaneous spectral energy distributions of 3C 279 prior to and near to the flare peak. The γ-rays vary by more than the square of the observed IR-optical Stanford, CA 94305

The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by the combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely low in-orbit background based on a combination of new techniques, including the concept of a well-type active shield counter. With an effective area of $142 \,\mathrm{cm}^{2}$ at 20 keV and $273 \,\mathrm{cm}^{2}$ at 150 keV, the background level at sea level reached $\sim 1 \times 10^{-5} \,\mathrm{cts} \,\mathrm{s}^{-1} \,\mathrm{cm}^{-2} \,\mathrm{keV}^{-1}$ at 30 keV for the PIN diodes, and $\sim 2 \times 10^{-5} \,\mathrm{cts} \,\mathrm{s}^{-1} \,\mathrm{cm}^{-2} \,\mathrm{keV}^{-1}$ at 100 keV, and $\sim 7 \times 10^{-6} \,\mathrm{cts} \,\mathrm{s}^{-1} \,\mathrm{cm}^{-2} \,\mathrm{keV}^{-1}$ at 200 keV for the phoswich counter. Tight active shielding of the HXD results in a large array of guard counters surrounding the main detector parts. These anti-coincidence counters, made of $\sim 4 \,\mathrm{cm}$ thick BGO crystals, have a large effective area for sub-MeV to MeV $\gamma$-rays. They work as an excellent $\gamma$-ray burst monitor with limited angular resolution ($\sim 5^{\circ}$). The on-board signal-processing system and the data transmitted to the ground are also described.

No abstract

Sugar-derived reactive carbonyls (RCs), including methylglyoxal (MG), are aggressive by-products of oxidative stress known to impair the functions of multiple proteins. These advanced glycation end-products accumulate in patients with diabetes mellitus and cause major complications, including arteriosclerosis and cardiac insufficiency. In the glycolytic pathway, the equilibration reactions between dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (GAP) have recently been shown to generate MG as a by-product. Because plants produce vast amounts of sugars and support the same reaction in the Calvin cycle, we hypothesized that MG also accumulates in chloroplasts. Incubating isolated chloroplasts with excess 3-phosphoglycerate (3-PGA) as the GAP precursor drove the equilibration reaction toward MG production. The rate of oxygen (O2) evolution was used as an index of 3-PGA-mediated photosynthesis. The 3-PGA- and time-dependent accumulation of MG in chloroplasts was confirmed by HPLC. In addition, MG production increased with an increase in light intensity. We also observed a positive linear relationship between the rates of MG production and O2 evolution (R = 0.88; P < 0.0001). These data provide evidence that MG is produced by the Calvin cycle and that sugar-derived RC production is inevitable during photosynthesis. Furthermore, we found that MG production is enhanced under high-CO2 conditions in illuminated wheat leaves.

No abstract