The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.

Using data from a blank experiment with wheat it was found that the regression of the logarithms of the variances for plots of different areas on the logarithms of their areas was approximately linear. A graphical review of variances, etc., reported in the literature for thirty-nine other blank experiments indicates that the results of most such experiments conform to the same law.It is shown that the above law can be generalized (so as to be applicable to any size of field) by applying a certain adjustment to the regression coefficient b', so as to give a modified coefficient b applicable to an “infinite” field.From this generalized relationship there has been deduced an expression ((4), p. 16) to indicate average relative efficiencies to be expected for randomized block experiments with varying numbers of plots per block in a field for which the coefficient b is known.A formulae (5), which may be used to estimate the most efficient size of plot for any given experiment, has also been deduced. The cost of using plots of other than the most efficient size is indicated graphically in Fig. 7.

The risk for diarrhea-associated HUS was higher for children infected with Escherichia coli O157 phage type (PT) 2 and PT21/28 than for those infected with other PTs.

The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions. KCC2 dysfunction has been implicated in human epilepsy, but to date, no monogenic KCC2-related epilepsy disorders have been described. Here we show recessive loss-of-function SLC12A5 mutations in patients with a severe infantile-onset pharmacoresistant epilepsy syndrome, epilepsy of infancy with migrating focal seizures (EIMFS). Decreased KCC2 surface expression, reduced protein glycosylation and impaired chloride extrusion contribute to loss of KCC2 activity, thereby impairing normal synaptic inhibition and promoting neuronal excitability in this early-onset epileptic encephalopathy.

A total of 3429 isolations of verocytotoxin-producing Escherichia coli O157 (VTEC O157) was con®rmed from human sources in England and Wales during the period 1995±1998. The largest annual total was 1087 in 1997. Most infections occurred in the third quarter of each year. The overall rate of infection ranged from 1.28 to 2.10=100 000 population and showed regional variation. The highest incidence was in children aged 1±4 years. Annually, between 5% and 11% of strains were from patients who had travelled abroad. There were 67 general outbreaks of infection represented by 407 (11.9%) VTEC O157 isolates. Outbreaks involved transmission by contaminated food or water, person-toperson spread and direct or indirect animal contact, and ®ve were associated with foreign travel. The majority (76%) of strains carried verocytotoxin (VT) 2 genes and 23.3% were VT1 VT2. Most strains had the¯agellar antigen H7, but c. 14% were non-motile. Approximately 20% of isolates were resistant to antimicrobial agents, predominantly streptomycin, sulphonamides and tetracycline. In addition to VTEC O157, strains of serogroup O157 that did not possess VT genes were identi®ed. These were either derivatives of VTEC O157 that had lost VT genes or were strains with H antigens other than H7 that have never been associated with VT production. Strains of VTEC other than O157 were characterised. Most were associated with diarrhoea, bloody diarrhoea or haemolytic uraemic syndrome and had virulence markers in addition to VT.