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A 78-year-old man presented with an esophageal polyp that was confirmed by immunohistochemistry and electron microscopy to be malignant fibrous histiocytoma. The tumor was comprised of a proliferation of spindle-shaped cells admixed with bizarre giant cells. These tumor cells were immunoreactive for smooth muscle actin, vimentin, alpha-1-anti-chymotrypsin and CD68. Electron microscopic examination revealed the myofibroblastic and histiocytic features of the tumor cells. No elements of epithelial or myogenic differentiation were found in the tumor. Malignant fibrous histiocytoma of the esophagus is extremely rare, with 10 cases being documented so far in the literature. The differential diagnosis of pleomorphic tumors of the esophagus is discussed.

-The secretory function of the remnant of the resected stomach together with the proteolytic activity of urine was compared among various types of gastrectomy in reference to the site and the degree of resection and to atrophic gastritis in the remnant. The surgical removal of pyloric antrum was found to lower or lose the proteolytic activity of gastric juice at pH 3.5 or higher, but not of urine. Atrophic gastritis in the remnant of the resected stomach was also found to influence the acid and protease secretion of the stomach in the parallel manner, but this is less clearly seen in the proteolytic activity of urine. The step-wise dissociation between acid and protease secretion and between synthesis and secretion of protease was demonstrated as the characteristic feature of the functional disturbance of the stomach due to atrophic gastritis. Namely, the abolition of acid secretion precedes that of pepsinogen secretion and then pepsinogen continues to be synthesized and excreted into urine after the cessation of its secretion into the gastric lumen. The difference of the inborn resisting capacity among different types of secretory cells was suggested as an important contributing factor. The importance of the simultaneous measurement of the gastric and urinary proteolytic activity was stressed in order to evaluate the histologic and functional status of gastric mucosa precisely.The secreting secretory cell mass was proposed to represent reasonably the gastric secretory response obtained by the maximal stimulation. -gastric secretion; pepsin; uropepsin; gastrectomy ; atrophic gastritis In relation to the various nutritional disturbances appearing after gastrectomy, the influence of the surgical removal of gastric mucosa and gastritis known to appear in high frequency in the remnant of the resected stomach upon the secretory function of the stomach has attracted attention of many investigators. It has been also shown that there is the dissociation among parietal cell, peptic cell and intrinsic factor secreting cell as to the degree of functional disturbance during the course of the various types of mucosal damage including gastritis (Doig et at. 1951, Poliner and Spiro 1958, Glass, et al. 1960.According to the recent reports (Seijffers et al. 1963, Kushner et al. 1964, Samloff 1969 it has been well established that the stomach elaborates several pepsinogens and their distribution on gastric mucosa differs from each other. It is the purpose of the present investigation to re-evaluate the influence of the surgical removal of Received for publication, July 21, 1971.

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