TRESK channel contributes to depolarizationinduced shunting inhibition and modulates epileptic seizuresGraphical abstract Highlights d A sustained seizure-like depolarization induces a transient shunting inhibition d This non-synaptic form of short-term plasticity contributes to seizure termination d TRESK, a subtype of K + channels, contributes to this shunting inhibition d Activating TRESK shortens seizure duration and prolongs postictal depression

Jack-up offshore platform is a type of important marine structure, which is mainly used for satellite launch, oil exploitation, and other engineering tasks in the offshore area. The offshore platform is bound to be subjected to wave loading in the course of use. Whether it can withstand the wave impact is an important engineering problem. To solve this engineering problem, the self-developed fluid–structure–foundation interaction coupling model OlaFlow-ABAQUS is used to explore the dynamic response characteristics of a jack-up offshore platform and its seabed foundation under three conventional wave conditions (wave height is 3, 5, and 7 m, respectively) in a coupled way. The numerical results show that only a small amplitude of periodic sloshing occurs for the jack-up offshore platform under the three conventional wave conditions. The maximum sloshing amplitude is up to 8 cm, and there is no visible residual displacement. It is indicated that there is no plastic deformation zone in the seabed foundation near the pile legs of the jack-up platform. It can thus be concluded that the jack-up platform has excellent stability under conventional wave conditions. Under conventional wave loading, momentary liquefaction occurs in the seabed foundation around the pile legs of the platform, and the maximum liquefaction depth is about 1 m. This study indicates that the coupling model OlaFlow-ABAQUS for the fluid–structure–foundation interaction is feasible, and has some advantages to study the dynamic response and to evaluate the stability of large-scale marine structures and their seabed foundations under ocean waves.

Ezrin protein is highly expressed in human PHC tissue which can be used for the prediction of metastasis disease.

PurposeLaparoscopic liver resection (LLR) is a widely practiced therapeutic method and holds several advantages over open liver resection (OLR) including less postoperative pain, lower morbidity, and faster recovery. However, the effect of LLR for the treatment of hepatocellular carcinoma (HCC) in elderly patients remains controversial. Therefore, we aimed to perform the first meta-analysis of propensity score-matched (PSM) studies to compare the short- and long-term outcomes of LLR versus OLR for elderly patients with HCC.MethodsDatabases including PubMed, Embase, Scopus, and Cochrane Library were systematically searched until April 2022 for eligible studies that compared LLR and OLR for the treatment of HCC in elderly patients. Short-term outcomes include postoperative complications, blood loss, surgical time, and length of hospital stay. Long-term outcomes include overall survival (OS) rate and disease-free survival (DFS) rate at 1, 3, and 5 years.ResultsA total of 12 trials involving 1,861 patients (907 in the LLR group, 954 in the OLR group) were included. Compared with OLR, LLR was associated with lower postoperative complications (OR 0.49, 95% CI 0.39 to 0.62, P < 0.00001, I2 = 0%), less blood loss (MD −285.69, 95% CI −481.72 to −89.65, P = 0.004, I2 = 96%), and shorter hospital stay (MD −7.88, 95% CI −11.38 to −4.37, P < 0.0001, I2 = 96%), whereas operation time (MD 17.33, 95% CI −6.17 to 40.83, P = 0.15, I2 = 92%) was insignificantly different. Furthermore, there were no significant differences for the OS and DFS rates at 1, 3, and 5 years.ConclusionsFor elderly patients with HCC, LLR offers better short-term outcomes including a lower incidence of postoperative complications and shorter hospital stays, with comparable long-term outcomes when compared with the open approach. Our results support the implementation of LLR for the treatment of HCC in elderly patients.Systematic review registrationhttps://inplasy.com/inplasy-2022-4-0156/, identifier INPLASY202240156.

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