Background: Gliomas are the most common form of malignant primary brain tumors in adults with an annual incidence of approximately five per 100,000 people. In Egypt, primary Central Nervous System (CNS) neoplasms are rare, constituting about 1-2% of all human neoplasms, with High Grade Gliomas (HGGs) being the most common type. The study aims to discover the histo-pathological aspect of HGGs, risk factors, and descriptive analysis of treatment received in Clinical oncology department affiliated with Alexandria University Hospital. Methods: Data were collected and analyzed for four hundred and thirty four patients with histologically proven HGGs in the period between 2003 and 2012. Results: Age of patients ranged from 21 to 83 years. Most cases (80.4%) were Glioblastoma Multiform (GBM), followed by Anaplastic Astrocytoma (AA) reaching14.3% of patients. In this study, 45.4% of patients had karnofsky performance score (KPS) more than 60%. Only 2.5% of patients underwent gross total resection (GTR), 25.6% underwent Subtotal Resection (STR) and 50% of patients underwent excisional biopsy. Patients received radiotherapy were 355 about 81.8% of patients with HGGs (80.2% of them received Radiotherapy (RT) only, 11.8% received RT followed by Adjuvant Chemotherapy (ACT), 4% received Concomitant Chemoradiotherapy (CCRT) and 4% received CCRT followed by ACT), 16.6% of patients received only best supportive care (BSC) and 2.3% did not receive treatment. The median Overall Survival (OS) was 10, 13, 19 and 15 months for patients received RT only, CCRT, CCRT followed by ACT and RT followed by ACT, respectively. Conclusion: Delayed presentation and inadequate GTR together with unavailability of TMZ could affect outcome in limited resource countries.

Background: Recurrent aphthous stomatitis (RAS) is the most common disorder affecting oral mucosa. The present study was designed to assess the clinical effectiveness of utilizing topical hyaluronic acid (HA) against chlorhexidine (CHX) mouthwashes as a control in RAS treatment.Materials and methods: Thirty-four patients with minor RAS were included in the trial. They were equally allocated into two groups with random distribution to rinse with CHX mouthwash as a control (Group I, CHX Group) and HA mouthwash in (Group II, HA group) as a study group. Evaluation of pain intensity and ulcer size were done in all study patients at baseline, 3 days and 7 days observational times. Duration of healing period was assessed in both study groups. Results:The results demonstrated a significant lowering in pain score and ulcer size in each group. Lower mean values of these outcomes were recorded in HA group compared to CHX group at 3 days and 7 days with significant difference regarding pain score. Concerning the duration of healing a significant decrease was recorded in HA group compared to CHX group. Conclusion:In conclusion, topical HA is a safe and effective treatment option for RAS with better pain control and healing duration.

Recent studies have shown that derivatives of natural extracts such as flavones may be used as

presented an event of interest for DDFS analyses. Five-year DDFS was 91,6%. Predictors for DDFS in univariate analysis were cT stage (c2¼45.408, p<0.001), AJCC Anatomic Stage Groups (c2¼ 110,784, p<0.001), and AJCC Clinical Prognostic Stage Groups (c2¼ 22,868, p¼0.001). In the multivariate analyse only AJCC anatomic stage groups retained significative results for DDFS (p<0,001).Conclusions: In our study, after pCR in breast cancer patients treated with NACT, only AJCC anatomic stage groups was significant for DDFS in the multivariate analyse. In this special population, these results emphasize the importance of meticulous staging at diagnosis and suggest the possibility of personalised follow-up and modulated adjuvant treatment after surgery based on AJCC anatomic stage groups.Legal entity responsible for the study: The authors.

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