Odontogenic keratocyst (OKC), and ameloblastoma (AB) aggressive epithelial odontogenic tumors with a high recurrence rate though, their aggressive nature are not totally understood, Many epithelial tumors are characterized by stromal reaction, Myofibroblast is one of stromal component that could contribute to the biologic behavior of these lesions, Fifteen cases of AB and OKC were operated on under general anesthesia, all cases were subjected to immunohistochemical staining with alpha-smooth muscle actin and flow cytometry analysis, ameloblastoma showed expression of α muscle actin between the follicles as well as around the blood vessels, while in OKC the expression was mostly in connective tissue wall of cyst lining, as well as flow cytometry analysis showed tumors were diploid and showed a percentage of cells in S-phase higher than 26%. OKC had a higher value than AB but the values were close and statistically insignificant, we concluded that the immunohistochemical expression of MF in AB & OKC has insignificant difference may contribute to the similar proliferative potential of both AB& OKC, as well The high proliferation rate of OKC reinforces its classification as a benign odontogenic neoplasm rather than a cyst Objective To detect the proliferative potential of odontogenic keratocyst, versus ameloblastoma and their correlation to presence of stromal myofibroblasts (258)

Background: Recurrent aphthous stomatitis (RAS) is the most common disorder affecting oral mucosa. The present study was designed to assess the clinical effectiveness of utilizing topical hyaluronic acid (HA) against chlorhexidine (CHX) mouthwashes as a control in RAS treatment.Materials and methods: Thirty-four patients with minor RAS were included in the trial. They were equally allocated into two groups with random distribution to rinse with CHX mouthwash as a control (Group I, CHX Group) and HA mouthwash in (Group II, HA group) as a study group. Evaluation of pain intensity and ulcer size were done in all study patients at baseline, 3 days and 7 days observational times. Duration of healing period was assessed in both study groups. Results:The results demonstrated a significant lowering in pain score and ulcer size in each group. Lower mean values of these outcomes were recorded in HA group compared to CHX group at 3 days and 7 days with significant difference regarding pain score. Concerning the duration of healing a significant decrease was recorded in HA group compared to CHX group. Conclusion:In conclusion, topical HA is a safe and effective treatment option for RAS with better pain control and healing duration.

Recent studies have shown that derivatives of natural extracts such as flavones may be used as

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Background: Osteosarcoma (OS) is the most common primary bone malignancy that affects children and adolescents. It is considered as a serious threat to the human health globally. For many years plants and natural constitutes components such as vitamin C (ascorbic acid), green tea have been used as anti-cancer drugs. Aim: The objective of this in vitro study was to investigate the effect of vitamin C, green tea and their combination on Mg-63 cell line. Material Methods: Treatment of cell line (Mg-63) by different concentrations of vitamin, green tea and their combination was done to evaluate the viability of the treated cells by SRB assay. Microscopic examination and were applied. Results: Regarding cytotoxicity effect of vitamin C, green tea and their combination on Mg-63cell line, it was noticed that cell distribution showed a variable arrest at different phase of cell division. Where there was nonsignificant difference of arrested cells of these drugs compared with its value in non-treated G0-G1 phase control cells while there was a significant elevated arrest of treated cells during the G2-M phase and the significant difference of cell arrest at G2-M phase was type of treatment related. Conclusion:From the results of the present study, we noticed that vitamin green tea and their combination have cytotoxic effect on Mg-63 cell line, it also induced an effect on the cell cycle distribution, resulting in apoptosis, necrosis and autophagy.