No abstract

The second paragraph in this section should be revised as follows:A less polar and deep purple cyclized didemnimide alkaloid 72 (with a trivial name of isogranulatimide) was first isolated from the Brazilian ascidian Didemnum granulatum (Subphylum Urochordata, Class Ascidiacea) in late 1998 by Berlinck et al. 1a Almost at the same time, Fenical's group independently obtained this compound from the Caribbean ascidian Didemnum conchyliatum. 2 Compound 72 is the cyclization product of didemnimide A 67 formed via a C-2 indole condensation with the imidazole nitrogen and represented the first alkaloid to be isolated with this cyclized indolemaleimide-imidazole structure. 1a,b,2 Isogranulatimide 72 and its isomer granulatimide 72A could be biomimetically synthesized involving the photocyclization of didemnimide A 67. 1a Subsequently, 72A along with its 6-bromo derivative (72B) were successively obtained as naturally occurring compounds from the above Brazilian ascidian. 1c Isogranulatimide 72 was reported as the first noncytotoxic, specific G2 cell cycle checkpoint inhibitor, 1a,b and the mechanism of this antitumor action was elucidated at molecular level in 2004. 1d

Physical chemistry Z 0225 Parameters for Evaluation of the Fate, Transport, and Environmental Impacts of Chemical Agents in Marine Environments -[321 refs.]. -(BIZZIGOTTI*, G. O.; CASTELLY, H.; HAFEZ, A. M.; SMITH, W. H. B.; WHITMIRE, M. T.; Chem.