Solid electrolytes are the most promising substitutes for liquid electrolytes to construct high‐safety and high‐energy‐density energy storage devices. Nevertheless, the poor lithium ion mobility and ionic conductivity at room temperature (RT) have seriously hindered their practical usage. Herein, single‐layer layered‐double‐hydroxide nanosheets (SLN) reinforced poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP) composite polymer electrolyte is designed, which delivers an exceptionally high ionic conductivity of 2.2 × 10−4 S cm−1 (25 °C), superior Li+ transfer number (≈0.78) and wide electrochemical window (≈4.9 V) with a low SLN loading (≈1 wt%). The Li symmetric cells demonstrate ultra‐long lifespan stable cycling over ≈900 h at 0.1 mA cm−2, RT. Moreover, the all‐solid‐state Li|LiFePO4 cells can run stably with a high capacity retention of 98.6% over 190 cycles at 0.1 C, RT. Moreover, using LiCoO2/LiNi0.8Co0.1Mn0.1O2, the all‐solid‐state lithium metal batteries also demonstrate excellent cycling at RT. Density functional theory calculations are performed to elucidate the working mechanism of SLN in the polymer matrix. This is the first report of all‐solid‐state lithium batteries working at RT with PVDF‐HFP based solid electrolyte, providing a novel strategy and significant step toward cost‐effective and scalable solid electrolytes for practical usage at RT.
The aim of this study was to investigate the cardioprotective effects and probable mechanism of ultrasound-targeted microbubble destruction (UTMD) combined with astragalus polysaccharide (APS) on diabetic cardiomyopathy (DCM) model rats. The DCM rats with diabetes and cardiomyopathy were induced via chronic treatment of doxorubicin and then randomly divided into the (1) DCM model group; (2) APS microbubble group; (3) UTMDgroup; and (4) APS microbubbles combined with UTMD group. After 4-week intervention, the fasting blood glucose levels, body weight, %HbA1c level and glucose tolerance of DCM rats received combination therapy were significantly improved as compared with those of UTMD or saline-treated ones. Moreover, the heart/body weight ratio, and myocardial contractility were all improved after receiving combination therapy groups compared with others. In addition, significantly upregulated activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) as well as significantly downregulated malondialdehyde (MDA) levels were all observed in the ones received combined treatment compared to others. Furthermore, the lipid accumulation and the expression levels of inflammatory factors were all significantly down-regulated in those ones received combination therapy compared with others (all
P
< 0.05). Further pathological analysis demonstrated that combination therapy effectively ameliorated fibrosis and myocardial morphological changes of DCM rats via activating the upregulation of AMPK and PPAR-γ signaling pathway, and inhibiting NF-κB activity in myocardial tissues of DCM rats. In conclusion, APS microbubbles combined with UTMD effectively protect the myocardial injury of DCM rats via activating AMPK signaling pathway to alleviate inflammation response, fibrosis and oxidative stress in myocardial tissues.
Recent works [PhysRevLett.125.170402 (2020) and PhysRevLett.125.043603 (2020)] verify that the perfect single-photon character is a global property of resonance fluorescence including all the spectral components, and then the absence of some components can spoil the single-photon character, which considerably limits the application of filtering scheme to obtain single-photon source (SPS) with subnatural linewidth. Here, we note that the linewidth of fluorescent photon is not always limited by the intrinsic linewidth of the emitter, and provide a scheme where the linewidth of the fluorescent single photon can be much smaller than the natural linewidth of emitter by manipulating external coherent fields. By simulating the response of the filter or detection setup with a bandwidth approaching and even much smaller than the natural linewidth of emitter, the realization of ultranarrow SPS can be confirmed. Besides, we demonstrate that this scheme of ultranarrow SPS can be implemented based on various real physical platforms.
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