A prevailing belief is that a sense of purpose in life is worth having, based on evidence that it predicts greater psychological functioning, social relationships, physical health, and longevity. Yet, whether the benefits of having a sense of purpose persist across all contents – or the actual substance of one’s aspirations – lingers as a critical blind spot within this literature. Here, we contend that an ecological systems perspective is needed to contextualize how purpose content either enables or extinguishes the benefits of feeling purposeful. We nominate congruence (the fit between a purpose and ecological conditions) and feasibility (the ease with which a purpose can be pursued) as measurable features of purpose content that fuse people and contexts and potentiate whether a sense of purpose proves favorable. Greater congruence and feasibility should orchestrate support for purpose-related goals, actions, and justifications, thus amplifying the likelihood of positive outcomes. Practical strategies for integrating the congruence and feasibility of individuals’ aspirations within the study of purpose are discussed.

BACKGROUND/OBJECTIVESThe objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model.MATERIALS/METHODSMale BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval. Vitamin C (60 mg/kg b.w. and 120 mg/kg b.w.) was supplemented by gavage for 5 weeks starting 2 d after the AOM injection.RESULTSThe vitamin C treatment suppressed inflammatory morbidity, as reflected by disease activity index (DAI) in recovery phase and inhibited shortening of the colon, and reduced histological damage. In addition, vitamin C supplementation suppressed mRNA levels of pro-inflammatory mediators and cytokines, including cyclooxygenase-2, microsomal prostaglandin E synthase-2, tumor necrosis factor-α, Interleukin (IL)-1β, and IL-6, and reduced expression of the proliferation marker, proliferating cell nuclear antigen, compared to observations of AOM/DSS animals. Although the microbial composition did not differ significantly between the groups, administration of vitamin C improved the level of inflammation-related Lactococcus and JQ084893 to control levels.CONCLUSIONVitamin C treatment provided moderate suppression of inflammation, proliferation, and certain inflammation-related dysbiosis in a murine model of colitis associated-early colon cancer. These findings support that vitamin C supplementation can benefit colonic health. Long-term clinical studies with various doses of vitamin C are warranted.

Biases perpetuate when people think that they are innocent whereas others are guilty of biases. We examined whether people would detect biased thinking and behavior in others but not themselves as influenced by preexisting beliefs (myside bias) and social stigmas (social biases). The results of three large studies showed that, across demographic groups, participants attributed more biases to others than to themselves, and that this self-other asymmetry was particularly salient among those who hold strong beliefs about the existence of biases (Study 1 and Study 2). The self-other asymmetry in bias recognition dissipated when participants made simultaneous predictions about others' and their own thoughts and behaviors (Study 3). People thus exhibit bias in bias recognition, and this metacognitive bias may be remedied when it is highlighted to people that we are all susceptible to biasing influences.

People tend to perceive themselves more favourably than others, but the degree to which individuals exhibit this bias may be influenced by cultural upbringing. Korean ( n = 271) and American ( n = 503) participants were asked to evaluate current and future health expectations for themselves and others. Results showed that American participants rated their own future health more positively than others' future health, whereas Korean participants rated their own and others' future health similarly. Given its role in patient health behaviour, implications for creating context-sensitive interventions for future health expectations are discussed.

Oxygenation of the Proterozoic atmosphere caused the progressive build-up of dissolved sulphate on the continents and in marine environments. However, oxygen levels in the Proterozoic were low enough to allow the early burial of biological material into low redox potential environments where permineralization and the authigenic replacement of organic material, including micro-organisms, occurred by a range of minerals. Consequently, microbial sulphate reduction caused the widespread degradation of organic matter and, where iron was available, the precipitation of pyrite. By contrast, where sulphate levels were low, early preservation by other minerals (e.g. phosphate or silica) could be excellent. We show, using two Proterozoic lake sequences with low and high sulphate chemistries, but with otherwise similar characteristics, that microbial sulphate reduction caused a profound loss of morphological detail and diversity within preserved microfossils. The results could imply that there is a significant bias in the Proterozoic fossil record towards low sulphate environments, which were in reality relatively scarce.Gold Open Access: This article is published under the terms of the CC-BY 3.0 license.